Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/28719
Title: Direct sequential C-H iodination/organoyl-thiolation for the benzenoid A-ring modification of quinonoid deactivated systems: a new protocol for potent trypanocidal quinones
Authors: Jardim, Guilherme A. M.
Oliveira, Willian X. C.
Freitas, Rossimiriam P. de
Menna-Barreto, Rubem F. S.
Silva, Thaissa L.
Goulart, Marilia O. F.
Silva Júnior, Eufrânio N. da
Affilliation: Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil.
Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil.
Abstract: We report a sequential C-H iodination/organoyl-thiolation of naphthoquinones and their relevant trypanocidal activity. Under a combination of AgSR with a copper source, sulfur-substituted benzenoid quinones were prepared in high yields (generally >90%). This provides an efficient and general method for preparing A-ring modified naphthoquinoidal systems, recognized as a challenge in quinone chemistry.
Keywords: Chemistry
new protocol
potent trypanocidal quinones
naphthoquinoidal systems
quinone chemistry
keywords: Química
quinonas tripanocidas potentes
novo protocolo
sistemas naftoquinoidais
química de quinona
Issue Date: 2018
Publisher: Royal Society of Chemistry
Citation: JARDIM, Guilherme A. M. et al. Direct sequential C–H iodination/organoylthiolation for the benzenoid A-ring modification of quinonoid deactivated systems: a new protocol for potent trypanocidal quinones. Org. Biomol. Chem., v.16, p.1686-1691, 2018.
DOI: 10.1039/c8ob00196k
ISSN: 1477-0520
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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