Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/28720

Type
Article
Copyright
Open access
Collections
Share

Statistics
Metadata
Show full item record

DISSECTING THE PHYLOEPIDEMIOLOGY OF TRYPANOSOMA CRUZI I (TCI) IN BRAZIL BY THE USE OF HIGH RESOLUTION GENETIC MARKERS
Roman, Fabiola et al. | Date Issued: 2018
Author
Roman, Fabiola
Xavier, Samanta das Chagas
Messenger, Louisa A.
Pavan, Márcio G.
Miles, Michael A.
Jansen, Ana Maria
Yeo, Matthew
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia dos Tripanossomatídeos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia dos Tripanossomatídeos. Rio de Janeiro, RJ. Brasil.
London School of Hygiene and Tropical Medicine. Faculty of Infectious and Tropical Diseases. Department of Infection and Immunity. London, United Kingdom.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ. Brasil.
London School of Hygiene and Tropical Medicine. Faculty of Infectious and Tropical Diseases. Department of Infection and Immunity. London, United Kingdom.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia dos Tripanossomatídeos. Rio de Janeiro, RJ. Brasil.
London School of Hygiene and Tropical Medicine. Faculty of Infectious and Tropical Diseases. Department of Infection and Immunity. London, United Kingdom.
Abstract
Trypanosoma cruzi, the causal agent of Chagas disease, is monophyletic but genetically heterogeneous. It is currently represented by six genetic lineages (Discrete Typing Units, DTUs) designated TcI-TcVI. TcI is the most geographically widespread and genetically heterogeneous lineage, this as is evidenced by a wide range of genetic markers applied to isolates spanning a vast geographic range in Latin America.
Keywords in Portuguese
Trypanosoma cruzi
Filoepidemiologia
Alta resolução
Marcadores genéticos
Brasil
 
Keywords
Trypanosoma cruzi
phyloepidemiology
genetic markers
high resolution
Brazil
 
Publisher
Public Library of Science
Citation
ROMAN, Fabiola; et al. Dissecting the phyloepidemiology of Trypanosoma cruzi I (TcI) in Brazil by the use of high resolution genetic markers. PLoS Negl Trop Dis., v.12, n.5, e0006466, 28p, May 2018.
DOI
10.1371/journal.pntd.0006466
ISSN
1935-2727