Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/28807
Title: Quality of life among HIV-infected individuals failing first-line antiretroviral therapy in resource-limited settings
Authors: Torres, Thiago S
Harrison, Linda J
La Rosa, Alberto M
Lavenberg, Jeffrey A
Zheng, Lu
Safren, Steven A
Ngongondo, McNeil
Poongulali, Selvamuthu
Matoga, Mitch
Samaneka, Wadzanai
Collier, Ann C
Hughes, Michael D
Affilliation: Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA / Fundação Oswaldo Cruz.Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA
Asociación Civil Impacta Salud y Educación, Lima, Peru
Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA
Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA
Department of Psychology, University of Miami, Miami, FL, USA
Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA / UNC Project Lilongwe, Lilongwe, Malaw
YRGCARE Medical Centre, VHS, Chennai, India
UNC Project Lilongwe, Lilongwe, Malawi
Department of Medicine, University of Zimbabwe-University of California Collaborative Research Programme, Harare, Zimbabwe
Department of Medicine, University of Washington, Seattle, WA, USA
Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA, USA
Abstract: We evaluated health-related quality of life (QoL) in HIV infection participants with virologic failure (VF) on first-line antiretroviral therapy (ART) in 9 resource-limited settings (RLS). ACTG SF-21 was completed by 512 participants at A5273 study entry; 8 domains assessed: general health perceptions (GHP), physical functioning (PF), role functioning (RF), social functioning (SF), cognitive functioning (CF), pain (P), mental health (MH), and energy/fatigue (E/F); each was scored between 0 (worst) to 100 (best). Mean QoL scores ranged from 67 (GHP) to 91 (PF, SF, CF). QoL varied by country; high VL and low CD4 were associated with worse QoL in most domains, except RF (VL only), SF (CD4 only) and CF (neither). Number of comorbidities, BMI and history of AIDS were associated with some domains. Relationships between QoL and VL varied among countries for all domains. The association of worse disease status with worse QoL may reflect low QoL when ART was initiated and/or deterioration associated with VF.
Keywords: Health-related quality of life
HIV
Virologic failure
Antiretroviral Therapy
Resource-limited settings
Issue Date: 2018
Citation: TORRES, Thiago S. et al. Quality of life among HIV-infected individuals failing first-line antiretroviral therapy in resource-limited settings. Aids Care, v. 30, n. 8, p. 954 - 962, 2017.
DOI: 10.1080/09540121.2018.1427207
ISSN: 0954-0121
Copyright: restricted access
Appears in Collections:INI - Artigos de Periódicos



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