| Author | Andrade Neto, Valter Viana | |
| Author | Cunha Junior, Edezio Ferreira | |
| Author | Faioes, Viviane dos Santos | |
| Author | Martins, Thais Pereira | |
| Author | Silva, Raphaela Lopes | |
| Author | Leon, Leonor Laura | |
| Author | Santos, Eduardo Caio Torres | |
| Access date | 2018-09-18T12:23:40Z | |
| Available date | 2018-09-18T12:23:40Z | |
| Document date | 2018 | |
| Citation | ANDRADE NETO, Valter Viana et al. Leishmaniasis treatment: update of possibilities for drug repurposing. Frontiers in Bioscience, v. 23, p. 967-996, Jan. 2018. | pt_BR |
| ISSN | 1093-9946 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28846 | |
| Description | Inclui tabela - Species pathogenic to human, occurrence and clinical manifestation. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Frontiers in BioScience | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmaniose | pt_BR |
| Subject in Portuguese | Reposicionamento de Medicamentos | pt_BR |
| Subject in Portuguese | Tratamento | pt_BR |
| Subject in Portuguese | Revisão | pt_BR |
| Title | Leishmaniasis treatment: update of possibilities for drug repurposing | pt_BR |
| Type | Article | pt_BR |
| Abstract | The leishmaniases represent a public health problem in under-developed countries and are considered a neglected disease by the World Health Organization (WHO). They are cuased by Leishmania parasites with different clinical manifestations. Currently, there is no vaccine, and treatment is in-efficient and is associated with both serious side effects often leading to resistance to the parasites. Thus, it is essential to search for new treatment strategies, such as drug repurposing, i.e., the use of drugs that are already used for other diseases. The discovery of new clinical applications for approved drugs is strategic for lowering the cost of drug discovery since human toxicity assays are already conducted. Here, we review a broad analysis of the different aspects of this approach for anti-leishmanial treatment. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leishmaniasis | pt_BR |
| Subject | Treatment | pt_BR |
| Subject | Drug Repurposing | pt_BR |
| Subject | Review | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
