Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/28846
Title: Leishmaniasis treatment: update of possibilities for drug repurposing
Authors: Andrade Neto, Valter Viana
Cunha Junior, Edezio Ferreira
Faioes, Viviane dos Santos
Martins, Thais Pereira
Silva, Raphaela Lopes
Leon, Leonor Laura
Santos, Eduardo Caio Torres
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquimica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.
Abstract: The leishmaniases represent a public health problem in under-developed countries and are considered a neglected disease by the World Health Organization (WHO). They are cuased by Leishmania parasites with different clinical manifestations. Currently, there is no vaccine, and treatment is in-efficient and is associated with both serious side effects often leading to resistance to the parasites. Thus, it is essential to search for new treatment strategies, such as drug repurposing, i.e., the use of drugs that are already used for other diseases. The discovery of new clinical applications for approved drugs is strategic for lowering the cost of drug discovery since human toxicity assays are already conducted. Here, we review a broad analysis of the different aspects of this approach for anti-leishmanial treatment.
Keywords: Leishmaniasis
Treatment
Drug Repurposing
Review
keywords: Leishmaniose
Reposicionamento de Medicamentos
Tratamento
Revisão
Issue Date: 2018
Publisher: Frontiers in BioScience
Citation: ANDRADE NETO, Valter Viana et al. Leishmaniasis treatment: update of possibilities for drug repurposing. Frontiers in Bioscience, v. 23, p. 967-996, Jan. 2018.
Description: Inclui tabela - Species pathogenic to human, occurrence and clinical manifestation.
ISSN: 1093-9946
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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