Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/28909
Title: Biomarkers Associated with Death After Initiating Treatment for Tuberculosis and HIV in Patients with Very Low CD4 Cells
Authors: Sattler, Fred R
Chelliah, Daniel
Wu, Xingye
Sanchez, Alejandro
Kendall, Michelle A
Hogg, Evelyn
Lagat, David
Lalloo, Umesh
Veloso, Valdilea
Havlir, Diane V
Landay, Alan
Affilliation: Keck School of Medicine of the University of Southern California, Los Angeles, California
Keck School of Medicine of the University of Southern California, Los Angeles, California
Harvard School of Public Health, Boston, Massachusetts
Keck School of Medicine of the University of Southern California, Los Angeles, California
Harvard School of Public Health, Boston, Massachusetts
Social & Scientific Systems Inc., Silver Springs, Maryland
Moi University Clinical Research Center, Eldoret, Kenya
Enhancing Care Foundation, Durban University of Technology, Durban, South Africa
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil
University of California San Francisco, San Francisco, California
Rush Presbyterian Medical Center, Chicago, Illinois
Abstract: The risk of short-term death for treatment naive patients dually infected with Mycobacterium tuberculosis and HIV may be reduced by early anti-retroviral therapy. Of those dying, mechanisms responsible for fatal outcomes are unclear. We hypothesized that greater malnutrition and/or inflammation when initiating treatment are associated with an increased risk for death.
Keywords: Adaptive immunity; Human Immunodeficiency Virus; Innate immunity; Mycobacterium tuberculosis; Nutrition biomarkers; Predictors of mortality; Timing of antiretroviral therapy
Issue Date: 2018
Citation: SATTLER, F. R. et al. Biomarkers Associated with Death After Initiating Treatment for Tuberculosis and HIV in Patients with Very Low CD4 Cells. Pathogens & immunity, v. 3, n. 1, p. 46–62, 2018
DOI: 10.20411/pai.v3i1.235
ISSN: 2469-2964
Copyright: restricted access
Appears in Collections:INI - Artigos de Periódicos

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