Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/29052

Type
Article
Copyright
Restricted access
Embargo date
2030-01-01
Collections
Share

Statistics
Metadata
Show full item record

DIVERGENCE OF MACROPHAGE PHAGOCYTIC AND ANTIMICROBIAL PROGRAMS IN LEPROSY
Montoya, Dennis et al. | Date Issued: 2009
Author
Montoya, Dennis
Cruz, Daniel
Teles, Rosane M. B.
Lee, Delphine J.
Ochoa, Maria Teresa
Krutzik, Stephan R.
Chun, Rene
Schenk, Mirjam
Zhang, Xiaoran
Ferguson, Benjamin G.
Burdick, Anne E.
Sarno, Euzenir N.
Rea, Thomas H.
Hewison, Martin
Adams, John S.
Cheng, Genhong
Modlin, Robert L.
Affilliation
University of California Los Angeles. David Geffen School of Medicine. Department of Microbiology and Molecular Genetics. Los Angeles, CA, USA.
University of California Los Angeles. David Geffen School of Medicine. Division of Cardiology. Los Angeles, CA, USA.
University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA.
University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA.
University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA.
University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA.
University of California Los Angeles. David Geffen School of Medicine. Los Angeles/Orthopaedic Hospital Department of Orthopedic Surgery,. Los Angeles, CA, USA.
University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA.
University of California Los Angeles. David Geffen School of Medicine. Department of Microbiology and Molecular Genetics. Los Angeles, CA, USA.
University of California Los Angeles. David Geffen School of Medicine. Department of Microbiology and Molecular Genetics. Los Angeles, CA, USA.
University of Miami School of Medicine. Department of Dermatology and Cutaneous Surgery. Miami, FL, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de |Micobactérias. Rio de Janeiro, RJ. Brasil.
University of Southern California School of Medicine. Department of Dermatology. Los Angeles, CA, USA.
University of California Los Angeles. David Geffen School of Medicine. Los Angeles/Orthopaedic Hospital Department of Orthopedic Surgery,. Los Angeles, CA, USA.
University of California Los Angeles. David Geffen School of Medicine. Los Angeles/Orthopaedic Hospital Department of Orthopedic Surgery,. Los Angeles, CA, USA.
University of California Los Angeles. David Geffen School of Medicine. Department of Microbiology and Molecular Genetics. Los Angeles, CA, USA / University of California Los Angeles. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, CA, USA.
Abstract
Effective innate immunity against many microbial pathogens requires macrophage programs that upregulate phagocytosis and direct antimicrobial pathways, two functions generally assumed to be coordinately regulated. We investigated the regulation of these key functions in human blood-derived macrophages. Interleukin-10 (IL-10) induced the phagocytic pathway, including the C-type lectin CD209 and scavenger receptors, resulting in phagocytosis of mycobacteria and oxidized low-density lipoprotein. IL-15 induced the vitamin D-dependent antimicrobial pathway and CD209, yet the cells were less phagocytic. The differential regulation of macrophage functional programs was confirmed by analysis of leprosy lesions: the macrophage phagocytosis pathway was prominent in the clinically progressive, multibacillary form of the disease, whereas the vitamin D-dependent antimicrobial pathway predominated in the self-limited form and in patients undergoing reversal reactions from the multibacillary to the self-limited form. These data indicate that macrophage programs for phagocytosis and antimicrobial responses are distinct and differentially regulated in innate immunity to bacterial infections.
Keywords in Portuguese
Hanseníase
Imunidade Inata
Infecções Bacterianas
macrófagos fagocitários
programas antimicorbianos
 
Keywords
Leprosy
antimicrobial programs
macrophage phagocytic
innate immunity
bacterial infections
 
Publisher
Elsevier
Citation
MONTOYA, Dennis; et al. Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell Host Microbe. v. 6, n.4, p.343–353., Oct. 2009.
DOI
10.1016/j.chom.2009.09.002
ISSN
1931-3128