Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/29102
Title: HIV Drug Resistance in Adults Receiving Early vs. Delayed Antiretroviral Therapy: HPTN 052
Authors: Palumbo, Philip J.
Fogel, Jessica M.
Hudelson, Sarah E.
Wilson, Ethan A.
Hart, Stephen
Hovind, Laura
Piwowar-Manning, Estelle
Wallis, Carole
Papathanasopoulos, Maria A.
Morgado, Mariza G.
Saravanan, Shanmugam
Tripathy, Srikanth
Eron, Joseph J.
Gallant, Joel E.
McCauley, Marybeth
Gamble, Theresa
Hosseinipour, Mina C.
Kumarasamy, Nagalingeswaran
Hakim, James G.
Pilotto, Jose H.
Kumwenda, Johnstone
Akelo, Victor
Godbole, Sheela V.
Santos, Breno R.
Grinsztejn, Beatriz
Panchia, Ravindre
Chariyalertsak, Suwat
Makhema, Joseph
Badal-Faesen, Sharlaa
Chen, Ying Q.
Cohen, Myron S.
Eshleman, Susan H.
Affilliation: Department of Pathology. Johns Hopkins University School of Medicine. Baltimore, USA.
Department of Pathology. Johns Hopkins University School of Medicine. Baltimore, USA.
Department of Pathology. Johns Hopkins University School of Medicine. Baltimore, USA.
Vaccine and Infectious Disease Division. Fred Hutchinson Cancer Research Center. Seattle, USA.
Frontier Science and Technology Research Foundation. Amherst. NY, USA.
Frontier Science and Technology Research Foundation. Amherst, NY, USA.
Department of Pathology. Johns Hopkins University School of Medicine. Baltimore, USA.
Specialty Molecular Division, Lancet Laboratories and BARC-SA. Johannesburg, South Africa.
HIV Pathogenesis Research Unit. Faculty of Health Sciences. University of the Witwatersrand. Johannesburg, South Africa.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Y. R. Gaitonde Centre for AIDS Research and Education, Chennai, India.
National Institute for Research in Tuberculosis, Chennai, India.
Department of Medicine. University of North Carolina at Chapel Hill. Chapel Hill, USA.
Department of Specialty Services. Southwest CARE Center. Santa Fe, USA.
HPTN Leadership and Operations Center. Washington, DC, USA.
HPTN Leadership and Operations Center. Durham, USA.
Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill/ UNC Project-Malawi, Institute for Global Health and Infectious Diseases, Lilongwe, Malawi
CART CRS, YRGCARE Medical Centre. VHS. Chennai, India.
Department of Medicine. University of Zimbabwe. Harare, Zimbabwe.
Hospital Geral de Nova Iguacu. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
College of Medicine-Johns Hopkins Project. Blantyre, Malawi.
Kenya Medical Research Institute (KEMRI)-Centers for Disease Control (CDC), Kisumu, Kenya.
Department of Epidemiology and Biostatistics. National AIDS Research Institute (ICMR). Pune, India.
Department of Infectious Diseases. Hospital Nossa Senhora da Conceição. Porto Alegre, RS, Brazil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Perinatal HIV Research Unit. University of the Witwatersrand. Soweto HPTN CRS. Soweto, South Africa.
Research Institute for Health Sciences. Chiang Mai University. Chiang Mai, Thailand.
Botswana-Harvard AIDS Institute Partnership. Gaborone, Botswana.
Clinical HIV Research Unit. Department of Internal Medicine. School of Clinical Medicine. Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
Vaccine and Infectious Disease Division. Fred Hutchinson Cancer Research Center. Seattle, WA.
Department of Medicine. University of North Carolina at Chapel Hill. Chapel Hill, USA.
Department of Pathology. Johns Hopkins University School of Medicine. Baltimore, USA.
Abstract: We evaluated HIV drug resistance in adults who received early vs. delayed antiretroviral therapy (ART) in a multinational trial [HIV Prevention Trials Network (HPTN) 052, enrollment 2005-2010]. In HPTN 052, 1763 index participants were randomized to start ART at a CD4 cell count of 350-550 cells/mm (early ART arm) or <250 cells/mm (delayed ART arm). In May 2011, interim study results showed benefit of early ART, and all participants were offered ART regardless of CD4 cell count; the study ended in 2015.
Keywords: HIV
HPTN 052
Early ART
Virologic failure
Resistance
Issue Date: 2018
Citation: PALUMBO, P. J. et al. HIV drug resistance in adults receiving early versus delayed antirretroviral therapy: HPTN 052. JAIDS, v. 77, n. 5, p. 484-491, 2018.
DOI: 10.1097/QAI.0000000000001623
ISSN: 1525-4135
Copyright: restricted access
Revised document: Não
Publication status: Não Publicado
Appears in Collections:IOC - Preprint
INI - Preprint

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