Please use this identifier to cite or link to this item:
Type
PreprintCopyright
Open access
Sustainable Development Goals
03 Saúde e Bem-EstarCollections
- BA - IGM - Preprint [97]
Metadata
Show full item record
HEME-MEDIATED CELL ACTIVATION: THE INFLAMMATORY PUZZLE OF SICKLE CELL ANEMIA
Author
Affilliation
Abstract
Introduction: Hemolysis triggers the onset of several clinical manifestations of sickle cell anemia (SCA). During hemolysis, heme, which is derived from hemoglobin (Hb), accumulates due to the inability of detoxification systems to scavenge sufficiently. Heme exerts multiple harmful effects, including leukocyte activation and migration, enhanced adhesion molecule expression by endothelial cells and the production of prooxidant molecules. Area covered: In this review, we describe the effects of heme on leukocytes and endothelial cells, as well as the features of vascular endothelial cells related to vasoocclusion in SCA. Expert commentary: Free Hb, heme and iron, potent cytotoxic intravascular molecules released during hemolysis, can exacerbate, modulate and maintain the inflammatory response, a main feature of SCA. Endothelial cells in the vascular environment, as well as leukocytes, can become activated via the molecular signaling effects of heme. Due to the hemolytic nature of SCA, hemolysis represents an interesting therapeutic target for heme-scavenging purposes.
Share