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2018-12-03
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ASSOCIATION OF AGE, BASELINE KIDNEY FUNCTION, AND MEDICATION EXPOSURE WITH DECLINES IN CREATININE CLEARANCE ON PRE-EXPOSURE PROPHYLAXIS: AN OBSERVATIONAL COHORT STUDY
Gandhi, Monica et al. | Date Issued: 2016
Author
Gandhi, Monica
Glidden, David V.
Mayer, Kenneth
Schechter, Mauro
Buchbinder, Susan
Grinsztejn, Beatriz
Hosek, Sybil
Casapia, Martin
Guanira, Juan
Bekker, Linda-Gail
Louie, Alexander
Horng, Howard
Benet, Leslie Z.
Liu, Albert
Grant, Robert M.
Affilliation
Division of HIV, Infectious Diseases, and Global Medicine. University of California, San Francisco. San Francisco, CA, USA.
Department of Biostatistics and Epidemiology. University of California San Francisco. San Francisco, CA, USA
Fenway Health. Boston, MA, USA.
Universidade Federal do Rio de Janeiro. Hospital Escola São Francisco de Assis. Projeto Praça Onze. Rio de Janeiro, RJ, Brasil.
San Francisco Department of Public Health. San Francisco, CA, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Department of Psychiatry. Stroger Hospital of Cook County. Chicago, IL, USA.
Asociacion Civil Selva Amazonica (ACSA) CRS. Iquitos, Peru.
Investigaciones Médicas en Salud. Lima, Peru.
Desmond Tutu Health Foundation. Faculty of Health Sciences. Cape Town, South Africa.
Department of Medicine. University of California, San Francisco. San Francisco, CA, USA.
Department of Bioengineering and Therapeutic Sciences. University of California, San Francisco. San Francisco, CA, USA.
HIV Prevention Intervention Studies Bridge HIV. San Francisco, CA, USA.
Division of Pulmonary and Critical Care Medicine. University of California, San Francisco. San Francisco, CA, USA.
Abstract
As pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine for the prevention of HIV infection is rolled out internationally, strategies to maintain effectiveness and to minimise adverse effects merit consideration. In this study, we aimed to assess reductions in renal function and predictors of renal toxicity in a large open-label study of PrEP.
Keywords
HIV prevention
Pre-exposure prophylaxis (PrEP)
Pharmacologic measures
Tenofovir/emtricitabine
Hair concentrations
iPrEx Open Label Extension (OLE)
Renal decline
Creatinine clearance
 
Citation
GANDHI, Monica. et al. Age, Baseline Kidney Function, and Medication Exposure Are Associated with Declines in Creatinine Clearance on PrEP: An Observational Cohort Study. The lancet HIV, v. 3, n. 11, p. e521–e528, 2016.
DOI
10.1016/S2352-3018(16)30153-9