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EMPIRICAL TUBERCULOSIS THERAPY VERSUS ISONIAZID IN ADULT OUTPATIENTS WITH ADVANCED HIV INITIATING ANTIRETROVIRAL THERAPY (REMEMBER): A MULTICOUNTRY OPEN-LABEL RANDOMISED CONTROLLED TRIAL
Hosseinipour, Mina C. et al. | Date Issued: 2016
Author
Hosseinipour, Mina C.
Bisson, Gregory P.
Miyahara, Sachiko
Sun, Xin
Moses, Agnes
Riviere, Cynthia
Kirui, Fredrick K.
Badal-Faesen, Sharlaa
Lagat, David
Nyirenda, Mulinda
Naidoo, Kogieleum
Hakim, James
Mugyenyi, Peter
Henostroza, German
Leger, Paul D.
Lama, Javier R.
Mohapi, Lerato
Alave, Jorge
Mave, Vidya
Veloso, Valdiléa G.
Pillay, Sandy
Kumarasamy, Nagalingeswaran
Bao, Jing
Hogg, Evelyn
Jones, Lynne
Zolopa, Andrew
Kumwenda, Johnstone
Gupta, Amita
Adult AIDS Clinical Trials Group A5274 (REMEMBER) Study Team
Affilliation
UNC Project, Lilongwe, Malawi; University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Perelman School of Medicine at the University of Pennsylvania, PA, USA.
Harvard University, Boston, MA, USA.
Harvard University, Boston, MA, USA.
UNC Project, Lilongwe, Malawi.
GHESKIO, Port-au-Prince, Haiti.
Kenya Medical Research Institute, Kisumu, Kenya.
Clinical HIV Research Unit, Department of Medicine, University of Witwatersrand, Johannesburg, South Africa.
Moi University School of Medicine, Eldoret, Kenya.
Johns Hopkins Project, Blantyre, Malawi.
Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.
University of Zimbabwe, Harare, Zimbabwe.
Joint Clinical Research Centre, Kampala, Uganda.
Centre for Infectious Diseases Research in Zambia, Lusaka, Zambia.
GHESKIO, Port-au-Prince, Haiti.
Asociacion Civil Impacta Salud y Educacion, Lima, Peru.
Perinatal HIV Research Unit, University of Witwatersrand, Johannesburg, South Africa.
BJ Medical College-Johns Hopkins Clinical Trials Unit, Pune, India.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Durban International CRS, Durban University of Technology, Durban, South Africa.
YRGCARE Medical Centre, VHS, Chennai, India.
HJF-DAIDS, a Division of The Henry M Jackson Foundation for the Advancement of Military Medicine, Contractor to National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Social and Scientific Systems, Silver Spring, MD, USA.
Frontier Science, Buffalo, NY, USA.
Stanford University, Palo Alto, CA, USA.
Johns Hopkins Project, Blantyre, Malawi.
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Abstract
Mortality within the first 6 months after initiating antiretroviral therapy is common in resource-limited settings and is often due to tuberculosis in patients with advanced HIV disease. Isoniazid preventive therapy is recommended in HIV-positive adults, but subclinical tuberculosis can be difficult to diagnose. We aimed to assess whether empirical tuberculosis treatment would reduce early mortality compared with isoniazid preventive therapy in high-burden settings.
Citation
HOSSEINIPOUR, M. C. et al. Empiric Tuberculosis Therapy versus isoniazid in advanced HIV-infected adult outpatients initiating antiretroviral therapy: a multi-country randomized controlled trial. Lancet (London, England), v. 387, n. 10024, p. 1198-1209, 2016.
DOI
10.1016/S0140-6736(16)00546-8
ISSN
0140-6736
Notes
Collaborators: Hosseinipour MC, Bisson GP, Kumwenda J, Zolopa A, Gupta A, Miyahara S, Sun X, Tierney C, Bao J, Hogg E, Jones L, Sise T, Borowski L, Mahachi R, Wallis C, Miiro F, Frye C, Bloom A, Badal-Faesen S, Rassool M, Mwelase N, Pillay S, Mngqibisa R, Alave J, Leon M, Valencia J, Rosas F, Lama JR, Montalban E, Kumarasamy N, Poonguali S, Hosseinipour M, Moses A, Matoga M, Ngongondo M, Kanyama C, Veloso VG, Garcia Ferreira AC, Grinsztejn B, Hoagland BR, Cardoso SW, Mohapi L, Mansfield B, Mugyenyi P, Kirui FK, Lagat D, Henostroza G, Kancheya N, Riviere C, Kumwenda J, Nyirenda M, Gunde L, Chiphwanya J, Kalonga B, Hakim J, Samaneka W, Chisada A, Nyatsambo P, Mahachi R, Naidoo K, Gengiah S, Samsunder N, Padayatchi N, Mave V, Kadam D, Patil S, Suryavanshi N, Nevekar N, Leger PD.