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PREVALENCE AND RISK FACTORS OF MICRONUTRIENT DEFICIENCIES PRE- AND POST-ANTIRETROVIRAL THERAPY (ART) AMONG A DIVERSE MULTICOUNTRY COHORT OF HIV-INFECTED ADULTS
Multiple micronutrients
Micronutrient deficiency
Antiretroviral therapy
Cohort studies
Vitamins
Author
Shivakoti, Rupak
Christian, Parul
Yang, Wei-Teng
Gupte, Nikhil
Mwelase, Noluthando
Kanyama, Cecilia
Pillay, Sandy
Samaneka, Wadzanai
Santos, Breno
Poongulali, Selvamuthu
Tripathy, Srikanth
Riviere, Cynthia
Berendes, Sima
Lama, Javier R.
Cardoso, Sandra W.
Sugandhavesa, Patcharaphan
Tang, Alice M.
Semba, Richard D.
Campbell, Thomas B.
Gupta, Amita
NWCS 319 and PEARLS Study Team
Christian, Parul
Yang, Wei-Teng
Gupte, Nikhil
Mwelase, Noluthando
Kanyama, Cecilia
Pillay, Sandy
Samaneka, Wadzanai
Santos, Breno
Poongulali, Selvamuthu
Tripathy, Srikanth
Riviere, Cynthia
Berendes, Sima
Lama, Javier R.
Cardoso, Sandra W.
Sugandhavesa, Patcharaphan
Tang, Alice M.
Semba, Richard D.
Campbell, Thomas B.
Gupta, Amita
NWCS 319 and PEARLS Study Team
Affilliation
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.
Department of Medicine, University of Witwatersrand, Johannesburg, South Africa.
UNC Lilongwe, Lilongwe, Private Bag, Malawi.
Durban International Clinical Research Site, Durban University of Technology, Durban, South Africa.
University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe.
Hospital Nossa Senhora de Conceição. Porto Alegre, Brasil.
YR Gaitonde Center for AIDS Research and Education, Chennai, India.
National AIDS Research Institute, Pune, India.
Les Centres GHESKIO, Port-Au-Prince, Haiti.
Malawi College of Medicine-Johns Hopkins University Research Project, Blantyre, Malawi.
Asociacion Civil Impacta Salud y Educacion, Lima, Peru.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Research Institute for Health Sciences, Chiang Mai, Thailand.
Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA.
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Medicine, Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, USA.
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.
Department of Medicine, University of Witwatersrand, Johannesburg, South Africa.
UNC Lilongwe, Lilongwe, Private Bag, Malawi.
Durban International Clinical Research Site, Durban University of Technology, Durban, South Africa.
University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe.
Hospital Nossa Senhora de Conceição. Porto Alegre, Brasil.
YR Gaitonde Center for AIDS Research and Education, Chennai, India.
National AIDS Research Institute, Pune, India.
Les Centres GHESKIO, Port-Au-Prince, Haiti.
Malawi College of Medicine-Johns Hopkins University Research Project, Blantyre, Malawi.
Asociacion Civil Impacta Salud y Educacion, Lima, Peru.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Research Institute for Health Sciences, Chiang Mai, Thailand.
Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA.
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Medicine, Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, USA.
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Abstract
HIV-infected adults have increased risk of several individual micronutrient deficiencies. However, the prevalence and risk factors of concurrent and multiple micronutrient deficiencies and whether micronutrient concentrations change after antiretroviral therapy (ART) initiation have not been well described. The objective of this study was to determine the prevalence and risk factors of individual, concurrent and multiple micronutrient deficiencies among ART-naïve HIV-infected adults from nine countries and assess change in micronutrient status 48 weeks post-ART initiation.
Keywords
HIVMultiple micronutrients
Micronutrient deficiency
Antiretroviral therapy
Cohort studies
Vitamins
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