Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/29540
Title: Chronic Hepatitis C: An Overview of Evidence on Epidemiology and Management from a Brazilian Perspective
Authors: Castro, Rodolfo
Perazzo, Hugo
Grinsztejn, Beatriz
Veloso, Valdilea G
Hyde, Chris
Affilliation: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
University of Exeter. University of Exeter Medical School. Evidence Synthesis and Modelling for Health Improvement (ESMI). Peninsula Technology Assessment Group (PenTAG). Institute of Health Research. South Cloisters, Exeter, UK
Abstract: Chronic hepatitis C remains one of the main causes of chronic liver disease worldwide and presents a variable natural history ranging from minimal changes to advanced fibrosis and cirrhosis and its complications, such as development of hepatocellular carcinoma. Approximately, 1.45 million people are estimated to be infected by HCV in Brazil representing a major public health issue. The aim of this paper was to review the epidemiology and management of chronic hepatitis C from a Brazilian perspective. The management of chronic hepatitis C has been challenged by the use of noninvasive methods to stage liver fibrosis as an alternative to liver biopsy and the high cost of new interferon-free antiviral treatments. Moreover, the need of cost-effectiveness analysis in hepatitis C and the recent changes in treatment protocols were discussed.
Issue Date: 2015
Citation: CASTRO, Rodolfo. et al. Chronic Hepatitis C: An Overview of Evidence on Epidemiology and Management from a Brazilian Perspective. International Journal of Hepatology, v. 2015, p. 852968, 2015
DOI: 10.1155/2015/852968
ISSN: 2090-3448
Copyright: open access
Appears in Collections:INI - Artigos de Periódicos



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