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CONCURRENT ANEMIA AND ELEVATED C-REACTIVE PROTEIN PREDICTS HIV CLINICAL TREATMENT FAILURE, INCLUDING TUBERCULOSIS, AFTER ANTIRETROVIRAL THERAPY INITIATION
Shivakoti, Rupak et al. | Date Issued: 2015
Author
Shivakoti, Rupak
Yang, Wei-Teng
Gupte, Nikhil
Berendes, Sima
Rosa, Alberto La
Cardoso, Sandra W
Mwelase, Noluthando
Kanyama, Cecilia
Pillay, Sandy
Samaneka, Wadzanai
Riviere, Cynthia
Sugandhavesa, Patcharaphan
Santos, Brento
Poongulali, Selvamuthu
Tripathy, Srikanth
Bollinger, Robert C
Currier, Judith S
Tang, Alice M
Semba, Richard D
Christian, Parul
Campbell, Thomas B
Gupta, Amita
New Work Concept Sheet 319
The Prospective Evaluation of Antiretrovirals in Resource-Limited Settings Study Team
Affilliation
Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, Maryland, USA.
Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, Maryland, USA.
Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, Maryland, USA.
Malawi College of Medicine-Johns Hopkins University Research Project. Blantyre.
Asociacion Civil Impacta Salud y Educacion. Lima, Peru.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
University of Witwatersrand. Department of Medicine. Johannesburg, South Africa.
University of North Carolina Lilongwe. Malawi.
Durban University of Technology. Durban International Clinical Research Site. South Africa.
University of Zimbabwe Clinical Research Centre. Harare.
Les Centres GHESKIO. Port-Au-Prince, Haiti.
Research Institute for Health Sciences. Chiang Mai, Thailand.
Hospital Nossa Senhora de Conceição. Porto Alegre, RS, Brasil.
Y. R. Gaitonde Center for AIDS Research and Education. Chennai.
National AIDS Research Institute. Pune, India.
Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, Maryland, USA.
University of California. Department of Medicine. Los Angeles, USA.
Tufts University School of Medicine. Department of Public Health and Community Medicine. Boston, Massachusetts, USA.
Johns Hopkins University School of Medicine. Department of Ophthalmology. USA.
Johns Hopkins Bloomberg School of Public Health. Department of International Health. Baltimore, Maryland, USA.
University of Colorado School of Medicine. Division of Infectious Diseases. Department of Medicine. Aurora, USA.
Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, Maryland, USA.
Abstract
Anemia is a known risk factor for clinical failure following antiretroviral therapy (ART). Notably, anemia and inflammation are interrelated, and recent studies have associated elevated C-reactive protein (CRP), an inflammation marker, with adverse human immunodeficiency virus (HIV) treatment outcomes, yet their joint effect is not known. The objective of this study was to assess prevalence and risk factors of anemia in HIV infection and to determine whether anemia and elevated CRP jointly predict clinical failure post-ART.
Keywords
HIV
Anemia
Inflammation
CRP
Antiretroviral therapy
 
Citation
SHIVAKOTI, Rupak. et al. Concurrent Anemia and Elevated C-Reactive Protein Predicts HIV Clinical Treatment Failure, Including Tuberculosis, After Antiretroviral Therapy Initiation. Clinical Infectious Diseases, v. 61, n. 1, p. 102–110, 2015
DOI
10.1093/cid/civ265
ISSN
1058-4838