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PARTNER-BASED ADHERENCE INTERVENTION FOR SECOND-LINE ANTIRETROVIRAL THERAPY (ACTG A5234): A MULTINATIONAL RANDOMISED TRIAL
Gross, Robert et al. | Date Issued: 2015
Author
Gross, Robert
Zheng, Lu
La Rosa, Alberto
Sun, Xin
Rosenkranz, Susan L.
Cardoso, Sandra Wagner
Ssali, Francis
Camp, Rob
Godfrey, Catherine
Cohn, Susan E.
Robbins, Gregory K.
Chisada, Anthony
Wallis, Carole L.
Reynolds, Nancy R.
Lu, Darlene
Safren, Steven A.
Hosey, Lara
Severe, Patrice
Collier, Ann C.
ACTG 5234 team
Affilliation
University of Pennsylvania Perelman School of Medicine, Medicine (Infectious Diseases) and Epidemiology. Philadelphia, PA, USA.
Harvard School of Public Health. Biostatistics. Boston, MA, USA.
Asociacion Civil IMPACTA Salud y Educacion. Lima, Peru.
Harvard School of Public Health. Biostatistics. Boston, MA, USA.
Harvard School of Public Health. Biostatistics. Boston, MA, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Joint Clinical Research Centre. Kampala, Uganda.
EUPATI. Barcelona, Spain.
National Institute of Allergy and Infectious Diseases. Bethesda, MD, USA.
Northwestern University Feinberg School of Medicine. Chicago, IL, USA.
Massachusetts General Hospital and Harvard Medical School. Boston, MA, USA.
University of Zimbabwe. Harare, Zimbabwe.
Lancet Laboratories. Johannesburg, South Africa.
Yale University School of Nursing. New Haven, CT USA.
Harvard School of Public Health. Biostatistics. Boston, MA, USA.
Massachusetts General Hospital and Harvard Medical School. Boston, MA, USA.
Social and Scientific Systems. Silver Spring, MD, USA.
GHESKIO. Port au Prince, Haiti.
University of Washington. Seattle, WA, USA.
Abstract
Adherence is key to the success of antiretroviral therapy. Enhanced partner support might benefit patients with previous treatment failure. We aimed to assess whether an enhanced partner-based support intervention with modified directly observed therapy would improve outcomes with second-line therapy in HIV-infected patients for whom first-line therapy had failed.
Citation
GROSS, Robert. et al. Partner-based adherence intervention for second-line antiretroviral therapy (ACTG A5234): a multinational randomised trial. The Lancet HIV, v. 2, n. 1, p. 12-19, 2015.
DOI
10.1016/S2352-3018(14)00007-1
ISSN
2405-4704
Notes
ACTG (AIDS Clinical Trials Group). The IPEC (INI - Fiocruz) site is one of the leading international sites in the ACTG network.