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PREDICTORS AND OUTCOMES OF MYCOBACTERIUM TUBERCULOSIS BACTEREMIA AMONG PATIENTS WITH HIV AND TUBERCULOSIS CO-INFECTION ENROLLED IN THE ACTG A5221 STRIDE STUDY
Crump, John A et al. | Date Issued: 2015
Author
Crump, John A
Wu, Xingye
Kendall, Michelle A
Ive, Prudence D
Kumwenda, Johnstone J
Grinsztejn, Beatriz
Jentsch, Ute
Swindells, Susan
Affilliation
Department of Medicine. Division of Infectious Diseases and International Health. Durham, NC, USA./ Duke University Medical Center. Department of Pathology. Durham, NC, USA./ Duke University. Duke Global Health Institute. Durham, NC, USA./ Kilimanjaro Christian Medical Centre. Moshi, Tanzania./ Tumaini University. Kilimanjaro Christian Medical University College. Moshi, Tanzania.
Harvard School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA.
Harvard School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA.
University of the Witwatersrand. Department of Medicine. Johannesburg, South Africa.
University of Malawi. College of Medicine. Department of Internal Medicine. Chichiri, Malawi.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
University of the Witwatersrand. School of Pathology. Johannesburg, South Africa.
University of Nebraska Medical Center. Division of Infectious Diseases, Department of Internal Medicine. Omaha, NE, USA.
Abstract
We evaluated predictors and outcomes of Mycobacterium tuberculosis bacteremia among participants undergoing baseline mycobacterial blood culture in the ACTG A5221 STRIDE study, a randomized clinical trial comparing earlier with later ART among HIV-infected patients suspected of having tuberculosis with CD4-positive T-lymphocyte counts (CD4 counts) <250 cells/mm(3). We conducted a secondary analysis comparing participants with respect to presence or absence of M. tuberculosis bacteremia.
Keywords
Africa
Asia
Bacteremia
HIV
Treatment outcome
Tuberculosis
 
Citation
CRUMP, J. A. et al. Predictors and Outcomes of Mycobacterium Tuberculosis Bacteremia among Patients with HIV and Tuberculosis Co-Infection Enrolled in the ACTG A5221 STRIDE Study. BMC Infectious Diseases, v. 15, p. 12, 2015
DOI
10.1186/s12879-014-0735-5
ISSN
1471-2334