| Author | Gazzinelli, Ricardo Tostes | |
| Author | Kalantari, Parisa | |
| Author | Fitzgerald, Katherine A. | |
| Author | Golenbock, Douglas Taylor | |
| Access date | 2018-10-23T12:47:01Z | |
| Available date | 2018-10-23T12:47:01Z | |
| Document date | 2014 | |
| Citation | GAZZINELLI, Ricardo Tostes et al. Innate sensing of malaria parasites. Nature Reviews Immunology, v. 14, n. 11, p. 744-757, 2014. | pt_BR |
| ISSN | 1474-1733 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29684 | |
| Language | eng | pt_BR |
| Publisher | Nature Pub. Group | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Vacinas contra Malária | pt_BR |
| Subject in Portuguese | Resposta imune | pt_BR |
| Subject in Portuguese | Vigilância Imunológica | pt_BR |
| Subject in Portuguese | Sistema imunológico | pt_BR |
| Title | Innate sensing of malaria parasites | pt_BR |
| Type | Article | |
| DOI | 10.1038/nri3742 | |
| Abstract | Innate immune receptors have a key role in immune surveillance by sensing microorganisms and initiating protective immune responses. However, the innate immune system is a classic 'double-edged sword' that can overreact to pathogens, which can have deleterious effects and lead to clinical manifestations. Recent studies have unveiled the complexity of innate immune receptors that function as sensors of Plasmodium spp. in the vertebrate host. This Review highlights the cellular and molecular mechanisms by which Plasmodium infection is sensed by different families of innate immune receptors. We also discuss how these events mediate both host resistance to infection and the pathogenesis of malaria. | pt_BR |
| Affilliation | Division of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA, USA / Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Division of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA, USA. | pt_BR |
| Affilliation | Division of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA, USA. | pt_BR |
| Affilliation | Division of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA, USA / Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | Malaria Vaccines | pt_BR |
| Subject | Immune response | pt_BR |
| Subject | Immunologic Surveillance | pt_BR |
| Subject | Immune system | pt_BR |
| Embargo date | 2100-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
