Innate sensing of malaria parasites

Division of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA, USA / Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.
Division of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA, USA.
Division of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA, USA.
Division of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA, USA / Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brasil.

Abstract

Innate immune receptors have a key role in immune surveillance by sensing microorganisms and initiating protective immune responses. However, the innate immune system is a classic 'double-edged sword' that can overreact to pathogens, which can have deleterious effects and lead to clinical manifestations. Recent studies have unveiled the complexity of innate immune receptors that function as sensors of Plasmodium spp. in the vertebrate host. This Review highlights the cellular and molecular mechanisms by which Plasmodium infection is sensed by different families of innate immune receptors. We also discuss how these events mediate both host resistance to infection and the pathogenesis of malaria.

Keywords in Portuguese

Vacinas contra Malária
Resposta imune
Vigilância Imunológica
Sistema imunológico

Keywords

Malaria Vaccines
Immune response
Immunologic Surveillance
Immune system

Publisher

Nature Pub. Group

Citation

GAZZINELLI, Ricardo Tostes et al. Innate sensing of malaria parasites. Nature Reviews Immunology, v. 14, n. 11, p. 744-757, 2014.

DOI

10.1038/nri3742

ISSN

1474-1733

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/29684

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Copyright

Restricted access

Embargo date

2100-01-01

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