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https://www.arca.fiocruz.br/handle/icict/29703
GENOME DETECTIVE: AN AUTOMATED SYSTEM FOR VIRUS IDENTIFICATION FROM HIGH-THROUGHPUT SEQUENCING DATA
Sistemas automatizados de registros médicos
Software
Aplicativos móveis
Genoma viral
Author
Affilliation
Emweb bvba. Herent, Belgium.
University of KwaZulu-Natal. School of Laboratory Medicine and Medical Sciences. Nelson R Mandela School of Medicine. College of Health Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa.
The Dutch National Institute for Public Health and the Environment. Bilthoven, The Netherlands.
University of KwaZulu-Natal. School of Laboratory Medicine and Medical Sciences. Nelson R Mandela School of Medicine. College of Health Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil.
Emweb bvba. Herent, Belgium.
Emweb bvba. Herent, Belgium.
Emweb bvba. Herent, Belgium.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Rega Institute for Medical Research. KU Leuven. Department of Microbiology and Immunology. Clinical and Epidemiological Virology. Leuven, Belgium.
Rega Institute for Medical Research. KU Leuven. Department of Microbiology and Immunology. Clinical and Epidemiological Virology. Leuven, Belgium / Universidade Nova de Lisboa. Instituto de Higiene e Medicina Tropical. Health and Tropical Medicine. Unidade de Microbiologia. Lisbon, Portugal.
Emweb bvba. Herent, Belgium.
University of KwaZulu-Natal. School of Laboratory Medicine and Medical Sciences. Nelson R Mandela School of Medicine. College of Health Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa.
University of KwaZulu-Natal. School of Laboratory Medicine and Medical Sciences. Nelson R Mandela School of Medicine. College of Health Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa.
The Dutch National Institute for Public Health and the Environment. Bilthoven, The Netherlands.
University of KwaZulu-Natal. School of Laboratory Medicine and Medical Sciences. Nelson R Mandela School of Medicine. College of Health Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil.
Emweb bvba. Herent, Belgium.
Emweb bvba. Herent, Belgium.
Emweb bvba. Herent, Belgium.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Rega Institute for Medical Research. KU Leuven. Department of Microbiology and Immunology. Clinical and Epidemiological Virology. Leuven, Belgium.
Rega Institute for Medical Research. KU Leuven. Department of Microbiology and Immunology. Clinical and Epidemiological Virology. Leuven, Belgium / Universidade Nova de Lisboa. Instituto de Higiene e Medicina Tropical. Health and Tropical Medicine. Unidade de Microbiologia. Lisbon, Portugal.
Emweb bvba. Herent, Belgium.
University of KwaZulu-Natal. School of Laboratory Medicine and Medical Sciences. Nelson R Mandela School of Medicine. College of Health Sciences. KwaZulu-Natal Research Innovation and Sequencing Platform. Durban, South Africa.
Abstract
Genome Detective is an easy to use web-based software application that assembles the
genomes of viruses quickly and accurately. The application uses a novel alignment method that
constructs genomes by reference-based linking of de novo contigs by combining amino-acids and
nucleotide scores. The software was optimized using synthetic datasets to represent the great diversity
of virus genomes. The application was then validated with next generation sequencing data of
hundreds of viruses. User time is minimal and it is limited to the time required to upload the data.
Keywords in Portuguese
VirusSistemas automatizados de registros médicos
Software
Aplicativos móveis
Genoma viral
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