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IMPACT OF LARGER SPUTUM VOLUME ON XPERT® MTB/RIF ASSAY DETECTION OF MYCOBACTERIUM TUBERCULOSIS IN SMEAR-NEGATIVE INDIVIDUALS WITH SUSPECTED TUBERCULOSIS
Badal-Faesen, Sharlaa et al. | Date Issued: 2017
Author
Badal-Faesen, Sharlaa
Firnhaber, Cynthia
Kendall, Michelle A.
Wu, Xingye
Grinsztejn, Beatriz
Escada, Rodrigo Otavio da Silva
Fernandez, Michel
Hogg, Evelyn
Sanne, Ian
Johnson, Pamela
Alland, David
Mazurek, Gerald H.
Benator, Debra A.
Luetkemeyer, Anne F.
AIDS Clinical Trials Group A5295
Tuberculosis Trials Consortium Study 34 Teams
Affilliation
University of Witwatersrand. Faculty of Health Sciences. School of Clinical Medicine. Department of Internal Medicine. Clinical HIV Research Unit. Johannesburg, South Africa.
University of Witwatersrand. Faculty of Health Sciences. School of Clinical Medicine. Department of Internal Medicine. Clinical HIV Research Unit. Johannesburg, South Africa.
Chan School of Public Health Boston. Harvard T.H. Center for Biostatistics in AIDS Research. Boston, MA, USA.
Chan School of Public Health Boston. Harvard T.H. Center for Biostatistics in AIDS Research. Boston, MA, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Baylor Scott and White Hospital. Pulmonary and Critical Care Department. Temple, TX, USA.
Social & Scientific Systems, Inc. Silver Spring, MD, USA.
University of Witwatersrand. Faculty of Health Sciences. School of Clinical Medicine. Department of Internal Medicine. Clinical HIV Research Unit. Johannesburg, South Africa.
Cepheid Inc. Sunnyvale, CA, USA.
Rutgers-New Jersey Medical School. Division of Infectious Disease. Newark, NJ, USA.
Centers for Disease Control and Prevention. Division of Tuberculosis Elimination. Atlanta, GA, USA.
The George Washington University. The Veterans Affairs Medical Center. Washington, DC, USA.
University of California. Zuckerberg San Francisco General. Infectious Diseases and Global Medicine. Division of HIV. San Francisco, CA, USA.
University of Witwatersrand. Faculty of Health Sciences. School of Clinical Medicine. Department of Internal Medicine. Clinical HIV Research Unit. Johannesburg, South Africa.
University of Witwatersrand. Faculty of Health Sciences. School of Clinical Medicine. Department of Internal Medicine. Clinical HIV Research Unit. Johannesburg, South Africa.
Abstract
As a strategy to improve the sensitivity of nucleic acid-based testing in acid-fast bacilli (AFB) negative samples, larger volumes of sputum (5-10 mL) were tested with Xpert® MTB/RIF from 176 individuals with smear-negative sputum undergoing tuberculosis evaluation. Despite larger volumes, this strategy had a suboptimal sensitivity of 50% (4/8).
Keywords
Xpert MTB/RIF
Larger volume sputum
Smear-negative suspects
 
Citation
BADAL-FAESEN, Sharlaa et al. Impact of Larger Sputum Volume on Xpert® MTB/RIF Assay Detection of Mycobacterium tuberculosis in Smear-Negative Individuals with Suspected Tuberculosis. Journal of Clinical Medicine, v. 6, n. 8, p. 1-4, 2017.
DOI
10.3390/jcm6080078
ISSN
2077-0383