Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/29856
Title: Undervaccination of perinatally HIV-infected and HIV-exposed uninfected children in Latin America and the Caribbean
Authors: Succi, Regina C. M.
Krauss, Margot R.
Harris, D. Robert
Machado, Daisy M.
Moraes-Pinto, Maria Isabel
Mussi-Pinhata, Marisa M.
Ruz, Noris Pavia
Pierre, Russell B.
Kolevic, Lenka
Joao, Esau
Foradori, Irene
Hazra, Rohan
Siberry, George K.
NISDI Pediatric Study Group 2012
Affilliation: Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, Brasil.
Westat. Rockville, Maryland, USA
Westat. Rockville, Maryland, USA
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, Brasil.
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, Brasil.
Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, Brasil.
Hospital Infantil de Mexico Federico Gomez. Depto. de Infectología. Clínica de Inmunodeficiencias. Ciudad de Mexico, Mexico.
University of the West Indies. Department of Child & Adolescent Health. Jamaica.
National Institute of Child Health and Faculty of Medicine of National University of San Marcos. Lima, Peru.
Hospital Federal dos Servidores do Estado. Rio de Janeiro, Brasil
Universidad de Buenos Aires (UBA). Facultad de Medicina. Ciudad de Buenos Aires, Argentina.
National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development. Pediatric Adolescent Maternal AIDS Branch. Bethesda, MD, USA.
National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development. Pediatric Adolescent Maternal AIDS Branch. Bethesda, MD, USA.
Abstract: BACKGROUND: Perinatally HIV-infected (PHIV) children may be at risk of undervaccination. Vaccination coverage rates among PHIV and HIV-exposed uninfected (HEU) children in Latin America and the Caribbean were compared. METHODS: All PHIV and HEU children born from 2002 to 2007 who were enrolled in a multisite observational study conducted in Latin America and the Caribbean were included in this analysis. Children were classified as up to date if they had received the recommended number of doses of each vaccine at the appropriate intervals by 12 and 24 months of age. Fisher's exact test was used to analyze the data. Covariates potentially associated with a child's HIV status were considered in multivariable logistic regression modeling. RESULTS: Of 1156 eligible children, 768 (66.4%) were HEU and 388 (33.6%) were PHIV. HEU children were significantly (P < 0.01) more likely to be up to date by 12 and 24 months of age for all vaccines examined. Statistically significant differences persisted when the analyses were limited to children enrolled before 12 months of age. Controlling for birth weight, sex, primary caregiver education and any use of tobacco, alcohol or illegal drugs during pregnancy did not contribute significantly to the logistic regression models. CONCLUSIONS: PHIV children were significantly less likely than HEU children to be up to date for their childhood vaccinations at 12 and 24 months of age, even when limited to children enrolled before 12 months of age. Strategies to increase vaccination rates in PHIV are needed.
Keywords: Pediatric HIV infection
Vaccination
Latin America
Issue Date: 2013
Citation: SUCCI, R. C. M. et al. Undervaccination of perinatally HIV-infected and HIV-exposed uninfected children in Latin America and the Caribbean. Pediatric infectious disease journal, v. 32, n. 8, p. 845-850, 2013.
Description: Presentes no NISDI Pediatric Study Group 2012: Beatriz Grinsztejn; Valdiléa Veloso (Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil).
DOI: 10.1097/INF.0b013e31828bbe68
ISSN: 0891-3668
Copyright: open access
Appears in Collections:INI - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Undervaccination of perinatally HIV_Beatriz_Grinsztejn_etal_INI_Lapclin-AIDS_2013.pdf64 kBAdobe PDFView/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.