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2030-01-01
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THE POTENTIAL OF SECONDARY METABOLITES FROM PLANTS AS DRUGS OR LEADS AGAINST PROTOZOAN NEGLECTED DISEASES - PART II
Romanha, A. J. et al. | Date Issued: 2012
Author
Romanha, A. J.
Alves, T. M.A.
Castro, Solange L. de
Leon, Leonor L.
Soeiro, Maria Nazaré
Múltipla autoria - ver em Notas - Lista de Autores
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Múltipla autoria - ver em Notas - Lista Afiliações.
Abstract
Infections with protozoan parasites are a major cause of disease and mortality in many tropical countries of the world. Diseases caused by species of the genera Trypanosoma (Human African Trypanosomiasis and Chagas Disease) and Leishmania (various forms of Leishmaniasis) are among the seventeen “Neglected Tropical Diseases” (NTDs) defined by the WHO. Furthermore, malaria (caused by various Plasmodium species) can be considered a neglected disease in certain countries and with regard to availability and affordability of the antimalarials. Living organisms, especially plants, provide an innumerable number of molecules with potential for the treatment of many serious diseases. The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs. In part I, a general description of the diseases, the current state of therapy and need for new therapeuticals, assay methods and strategies applied in the search for new plant derived natural products against these diseases and an overview on natural products of terpenoid origin with antiprotozoal potential were given. The present part II compiles the current knowledge on natural products with antiprotozoal activity that are derived from the shikimate pathway (lignans, coumarins, caffeic acid derivatives), quinones of various structural classes, compounds formed via the polyketide pathways (flavonoids and related compounds, chromenes and related benzopyrans and benzofurans, xanthones, acetogenins from Annonaceae and polyacetylenes) as well as the diverse classes of alkaloids. In total, both parts compile the literature on almost 900 different plant-derived natural products and their activity data, taken from over 800 references. These data, as the result of enormous efforts of numerous research groups world-wide, illustrate that plant secondary metabolites represent an immensely rich source of chemical diversity with an extremely high potential to yield a wealth of lead structures towards new therapies for NTDs. Only a small percentage, however, of the roughly 200,000 plant species on earth have been studied chemically and only a small percentage of these plants or their constituents has been investigated for antiprotozoal activity. The repository of plant-derived natural products hence deserves to be investigated even more intensely than it has been up to present.
Keywords in Portuguese
Doenças Negligenciadas
Trypanosoma
Leishmania
Malária
Produto natural
flavonóide
alcalóide
 
Keywords
Neglected tropical diseases
Trypanosoma
Leishmania
Plasmodium
natural product
lignan
coumarin
caffeic acid
flavonoid
chalcone
aurone
chromene
xanthone
acetogenin
polyacetylene
alkaloid
 
DeCS
Cumarínicos
Publisher
Bentham Science Publishers
Citation
SCHMIDT, T. J. et al. The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part II. Current Medicinal Chemistry, v.19.p.2176-2228, 2012.
ISSN
0929-8673
Notes
AUTHORS - T.J. Schmidt*,1, S.A. Khalid2, A.J. Romanha3,4, T.M.A. Alves4, M.W. Biavatti5, R. Brun6, F.B. Da Costa7, S.L. de Castro8, V.F. Ferreira9, M.V.G. de Lacerda10, J.H.G. Lago11, L.L. Leon12, N.P. Lopes7, R.C. das Neves Amorim13, M. Niehues7, I.V. Ogungbe14, A.M. Pohlit13, M.T. Scotti15, W.N. Setzer14, M. de N.C. Soeiro8, M. Steindel3 and A.G. Tempone16. AFFILIATIONS - 1Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, Hittorfstrasse 56, D-48149 Münster, Germany; 2Faculty of Pharmacy, University of Science & Technology, P.O.Box 447 Omdurman, Sudan; 3Universidade Federal de Santa Catarina (UFSC), Centro de Ciências Biológicas (CCB), Dept. de Microbiologia, Immunologia e Parasitologia (MIP); Florianópolis, SC, Brazil; 4Centro de Pesquisas René Rachou, Fiocruz, Av Augusto de Lima, 1715, Belo Horizonte-MG, 30190-002, Brazil; 5Universidade Federal de Santa Catarina (UFSC), Dept. de Farmácia, Campus Trindade, Bloco J/K, Trindade, Florianópolis, SC, Brazil; 6Swiss Tropical and Public Health Institute (STPH) and University of Basel, Socinstrasse 57, CH-4002 Basel, Switzerland; 7Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP-USP), Universidade de São Paulo, Av. do Café, s/n°, 14040-903, Ribeirão Preto, SP, Brazil; 8Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Avenida Brasil 4265, Manguinhos, Rio de Janeiro, RJ, Brazil; 9Instituto de Química, Departamento de Química Orgânica, Universidade Federal Fluminense, Campus do Valonguinho, Alameda Barros Terra s/n, 24020-150, Niterói, RJ, Brazil; 10Fundação de Medicina Tropical Heitor Vieira Dourado, Avenida Pedro Teixeira, 25, Dom Pedro, 69040-000, Manaus, AM, Brazil; 11Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Campus Diadema, Brazil; 12Laboratório de Bioquímica de Tripanosomatideos, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz,21040-900 Rio de Janeiro, RJ, Brazil; 13Instituto Nacional de Pesquisa da Amazonia, Avenida André Araújo, 2936, Aleixo, 69060-001, Manaus, AM, Brazil; 14Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, U.S.A; 15Departamento do Enghenaria e Meio Ambiente, Centro de Ciências Aplicadas e Educação, Universidade Federal da Paraíba - Campus IV, Rua da Mangeira s/n, Rio Tinto, Paraíba, Brazil; 16Departamento de Parasitologia, Instituto Adolfo Lutz, Avenida Dr. Arnaldo, 351, 8º andar. Cerqueira César, CEP 01246-902 - São Paulo/SP, Brazil.