| Author | Cordovil, Ivan | |
| Author | Huguenin, Grazielle | |
| Author | Rosa, Glorimar | |
| Author | Bello, Annie | |
| Author | Köhler, Onilmar | |
| Author | Moraes, Roger de | |
| Author | Tibiriçá, Eduardo | |
| Access date | 2018-11-08T15:13:53Z | |
| Available date | 2018-11-08T15:13:53Z | |
| Document date | 2012 | |
| Citation | CORDOVIL, Ivan; et al. Evaluation of systemic microvascular endothelial function using laser speckle contrast imaging. Microvascular Research, v.83, p.376-379, Jan. 2012. | pt_BR |
| ISSN | 0026-2862 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29963 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Avaliação | pt_BR |
| Subject in Portuguese | função endotelial microvascular sistêmica | pt_BR |
| Subject in Portuguese | speckle a laser | pt_BR |
| Subject in Portuguese | imagem de contraste | pt_BR |
| Title | Evaluation of systemic microvascular endothelial function using laser speckle contrast imaging | pt_BR |
| Type | Article | |
| Abstract | Objective: The aim of this study was to compare cutaneous microvascular function in young healthy subjects
(n=50) with that of cardiometabolic diseased patients (n=50) using laser speckle contrast imaging (LSCI)
coupled with transdermal iontophoretic delivery of acetylcholine (ACh) and post-occlusive reactive hyperemia
(PORH).
Methods: Cutaneous blood flow was assessed in the forearm using LSCI at rest, during PORH and during iontophoresis
of ACh with increasing anodal currents of 30, 60, 90, 120, 150 and 180 μA during 10-second intervals
spaced 1 min apart.
Results: Endothelium-dependent skin microvascular vasodilator responses induced by both ACh and PORH
were significantly reduced in cardiometabolic diseased patients compared to healthy subjects. Vasodilator
responses induced by ACh were significantly higher in young women than in young men. Iontophoresis
charges up to 1.5 mC do not induce nonspecific effects on skin microvascular flux.
Conclusion: LSCI appears to be a promising noninvasive technique for evaluating systemic microvascular endothelial
function. | pt_BR |
| Affilliation | Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro, Departamento de Nutrição e Dietética. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro, Departamento de Nutrição e Dietética. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | systemic microvascular endothelial function using laser speckle contrast imaging | pt_BR |
| Subject | contrast imaging | pt_BR |
| Subject | laser speckle | pt_BR |
| Subject | Evaluation | pt_BR |
| e-ISSN | 1095-9319 | |
| Embargo date | 2030-01-01 | |
