Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/29963
Title: Evaluation of systemic microvascular endothelial function using laser speckle contrast imaging
Authors: Cordovil, Ivan
Huguenin, Grazielle
Rosa, Glorimar
Bello, Annie
Köhler, Onilmar
Moraes, Roger de
Tibiriçá, Eduardo
Affilliation: Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro, Departamento de Nutrição e Dietética. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Nutrição Josué de Castro, Departamento de Nutrição e Dietética. Rio de Janeiro, RJ, Brasil.
Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil.
Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil.
Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Abstract: Objective: The aim of this study was to compare cutaneous microvascular function in young healthy subjects (n=50) with that of cardiometabolic diseased patients (n=50) using laser speckle contrast imaging (LSCI) coupled with transdermal iontophoretic delivery of acetylcholine (ACh) and post-occlusive reactive hyperemia (PORH). Methods: Cutaneous blood flow was assessed in the forearm using LSCI at rest, during PORH and during iontophoresis of ACh with increasing anodal currents of 30, 60, 90, 120, 150 and 180 μA during 10-second intervals spaced 1 min apart. Results: Endothelium-dependent skin microvascular vasodilator responses induced by both ACh and PORH were significantly reduced in cardiometabolic diseased patients compared to healthy subjects. Vasodilator responses induced by ACh were significantly higher in young women than in young men. Iontophoresis charges up to 1.5 mC do not induce nonspecific effects on skin microvascular flux. Conclusion: LSCI appears to be a promising noninvasive technique for evaluating systemic microvascular endothelial function.
Keywords: systemic microvascular endothelial function using laser speckle contrast imaging
contrast imaging
laser speckle
Evaluation
keywords: Avaliação
função endotelial microvascular sistêmica
speckle a laser
imagem de contraste
Issue Date: 2012
Publisher: Elsevier
Citation: CORDOVIL, Ivan; et al. Evaluation of systemic microvascular endothelial function using laser speckle contrast imaging. Microvascular Research, v.83, p.376-379, Jan. 2012.
ISSN: 0026-2862
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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