Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/29965
Title: Anti-inflammatory Effects of Aerobic Exercise in Mice Exposed to Air Pollution
Authors: Faria Neto, Hugo Caire Castro
Múltipla autoria - ver em Notas
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.
Múltipla autoria - ver em Notas (Afiliações)
Abstract: Purpose: Exposure to diesel exhaust particles (DEP) results in lung inflammation. Regular aerobic exercise improves the inflammatory status in different pulmonary diseases. However, the effects of long-term aerobic exercise on the pulmonary response to DEP have not been investigated. The present study evaluated the effect of aerobic conditioning on the pulmonary inflammatory and oxidative responses of mice exposed to DEP. Methods: BALB/c mice were subjected to aerobic exercise five times per week for 5 wk, concomitantly with exposure to DEP (3 mgImLj1; 10 KL per mouse). The levels of exhaled nitric oxide, reactive oxygen species, cellularity, interleukin 6 (IL-6), and tumor necrosis factor > (TNF->) were analyzed in bronchoalveolar lavage fluid, and the density of neutrophils and the volume proportion of collagen fibers were measured in the lung parenchyma. The cellular density of leukocytes expressing IL-1A, keratinocyte chemoattractant (KC), and TNF-> in lung parenchyma was evaluated with immunohistochemistry. The levels of IL-1A, KC, and TNF-> were also evaluated in the serum. Results: Aerobic exercise inhibited the DEP-induced increase in the levels of reactive oxygen species (P G 0.05); exhaled nitric oxide (P G 0.01); total (P G 0.01) and differential cells (P G 0.01); IL-6 and TNF-> levels in bronchoalveolar lavage fluid (P G 0.05); the level of neutrophils (P G 0.001); collagen density in the lung parenchyma (P G 0.05); the levels of IL-6, KC, and TNF-> in plasma (P G 0.05); and the expression of IL-1A, KC, and TNF-> by leukocytes in the lung parenchyma (P G 0.01). Conclusions: We conclude that long-term aerobic exercise presents protective effects in a mouse model of DEP-induced lung inflammation. Our results indicate a need for human studies that evaluate the pulmonary responses to aerobic exercise chronically performed in polluted areas.
Keywords: Aerobic training
immunology
lung inflammation
diesel exhaust particles
nitrosative stress
oxidative stress
keywords: Treinamento aeróbico
Imunologia
Inflamação pulmonar
estresse oxidativo
estresse nitrosativo
Issue Date: 2012
Publisher: Lippincott, Williams & Wilkins
Citation: VIEIRA, Rodolfo de Paula et al. Anti-inflammatory Effects of Aerobic Exercise in Mice Exposed to Air Pollution. Medicine & Science in Sports & Exercise, v. 44, n. 7, p.1227-1234, 2012.
Description: AUTHORS - RODOLFO DE PAULA VIEIRA1,2, ALESSANDRA CHOQUETA TOLEDO3, LUCAS BOGAZ SILVA1, FRANCINE MARIA ALMEIDA3, NILSA REGINA DAMACENO-RODRIGUES4, ELIA GARCIA CALDINI4, ANGELA BATISTA GOMES SANTOS1, DOLORES HELENA RIVERO1, DEBORAH CAMARGO HIZUME3, FERNANDA DEGOBBI TENO´ RIO QUIRINO SANTOS LOPES3, CLARICE ROSA OLIVO3, HUGO CAIRE CASTRO-FARIA-NETO 5, MILTON ARRUDA MARTINS3, PAULO HILÁRIO NASCIMENTO SALDIVA1, and MARISA DOLHNIKOFF1 - AFFILIATIONS - 1Laboratory of Experimental Air Pollution (LIM 05), Department of Pathology, University of Sa˜o Paulo, School of Medicine, Sa˜o Paulo, BRAZIL; 2Post Graduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, Sa˜o Paulo, BRAZIL; 3Laboratory of Experimental Therapeutics (LIM 20), Department of Clinical Medicine, School of Medicine, University of Sa˜o Paulo, Sa˜o Paulo, BRAZIL; 4Laboratory of Cellular Biology (LIM 59), Department of Pathology, School of Medicine, University of Sa˜o Paulo, Sa˜o Paulo, BRAZIL; and 5 Laboratory of Immunopharmacology, Oswaldo Cruz Foundation, Institute Oswaldo Cruz, Rio de Janeiro, BRAZIL.
DOI: 10195-9131/12/4407-1227/0
ISSN: 0195-9131
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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