| Author | Silva, Fernanda Fonseca | |
| Author | Inacio, Job D. F. | |
| Author | Canto-Cavalheiro, Marilene M. | |
| Author | Amaral, Elmo Eduardo Almeida | |
| Access date | 2018-11-15T15:07:28Z | |
| Available date | 2018-11-15T15:07:28Z | |
| Document date | 2011 | |
| Citation | SILVA, Fernanda Silva; et al. Reactive Oxygen Species Production and Mitochondrial Dysfunction Contribute to Quercetin Induced Death in Leishmania amazonensis. Plos One, v.6, n.2, e14666, 7p, Feb. 2011. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30043 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmania amazonensis | pt_BR |
| Subject in Portuguese | disfunção mitocondrial | pt_BR |
| Subject in Portuguese | quercetina | pt_BR |
| Subject in Portuguese | espécies de oxigênio | pt_BR |
| Subject in Portuguese | Produção reativa | pt_BR |
| Subject in Portuguese | Morte | pt_BR |
| Title | Reactive oxygen species production and mitochondrial dysfunction contribute to quercetin induced death in Leishmania amazonensis | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0014666 | |
| Abstract | Leishmaniasis, a parasitic disease caused by protozoa of the genus Leishmania, affects more than 12 million people worldwide. Quercetin has generated considerable interest as a pharmaceutical compound with a wide range of therapeutic activities. One such activity is exhibited against the bloodstream parasite Trypanosoma brucei and amastigotes of Leishmania donovani. However, the mechanism of protozoan action of quercetin has not been studied. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leishmania amazonensis | pt_BR |
| Subject | Oxygen Species | pt_BR |
| Subject | Reactive Production | pt_BR |
| Subject | Quercetin | pt_BR |
| Subject | Mitochondrial Dysfunction | pt_BR |
| Subject | Death | pt_BR |
