Reactive oxygen species production and mitochondrial dysfunction contribute to quercetin induced death in Leishmania amazonensis

Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil.

Abstract

Leishmaniasis, a parasitic disease caused by protozoa of the genus Leishmania, affects more than 12 million people worldwide. Quercetin has generated considerable interest as a pharmaceutical compound with a wide range of therapeutic activities. One such activity is exhibited against the bloodstream parasite Trypanosoma brucei and amastigotes of Leishmania donovani. However, the mechanism of protozoan action of quercetin has not been studied.

Keywords in Portuguese

Leishmania amazonensis
disfunção mitocondrial
quercetina
espécies de oxigênio
Produção reativa
Morte

Keywords

Leishmania amazonensis
Oxygen Species
Reactive Production
Quercetin
Mitochondrial Dysfunction
Death

Publisher

Public Library of Science

Citation

SILVA, Fernanda Silva; et al. Reactive Oxygen Species Production and Mitochondrial Dysfunction Contribute to Quercetin Induced Death in Leishmania amazonensis. Plos One, v.6, n.2, e14666, 7p, Feb. 2011.

DOI

10.1371/journal.pone.0014666

ISSN

1932-6203

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/30043

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