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GENETIC CHARACTERIZATION OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE 1 IN MOZAMBIQUE: TRANSCONTINENTAL LINEAGES DRIVE THE HTLV-1 ENDEMIC
Vicente, Ana Carolina P. et al. | Date Issued: 2011
Author
Vicente, Ana Carolina P.
Gudo, Eduardo Samo
Iñiguez, Alena Mayo
Otsuki, Koko
Bhatt, Nilesh
Abreu, Celina Monteiro
Vubil, Adolfo
Bila, Dulce
Ferreira, Orlando C.
Tanuri, Amílcar
Jani, Ilesh V.
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Instituto Nacional de Saúde. Departamento de Imunologia. Maputo, Mozambique.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Instituto Nacional de Saúde. Departamento de Imunologia. Maputo, Mozambique.
Universidade Federal do Rio de Janeiro. Departamento de Genética. Rio de Janeiro, RJ, Brasil.
Instituto Nacional de Saúde. Departamento de Imunologia. Maputo, Mozambique.
Instituto Nacional de Saúde. Departamento de Imunologia. Maputo, Mozambique.
Universidade Federal do Rio de Janeiro. Departamento de Genética. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Departamento de Genética. Rio de Janeiro, RJ, Brasil.
Instituto Nacional de Saúde. Departamento de Imunologia. Maputo, Mozambique.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Abstract
Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It has been estimated that 10-20 million people are infected worldwide, but no successful treatment is available. Recently, the epidemiology of this virus was addressed in blood donors from Maputo, showing rates from 0.9 to 1.2%. However, the origin and impact of HTLV endemic in this population is unknown.
Publisher
Public Library of Science
Citation
VICENTE, Ana Carolina P. et al. Genetic Characterization of Human T-Cell Lymphotropic Virus Type 1 in Mozambique: Transcontinental Lineages Drive the HTLV-1 Endemic. PLoS Negl Trop Dis., v.5, n.4, e1038, April 2011.
DOI
10.1371/journal.pntd.0001038
ISSN
1935-2727