Author | Morgado, Mariza | |
Author | WHO-UNAIDS Network for HIV Isolation and Characterisation | |
Author | Múltipla autoria - ver em Notas | |
Access date | 2018-11-18T13:25:40Z | |
Available date | 2018-11-18T13:25:40Z | |
Document date | 2011 | |
Citation | HEMELAAR, Joris; et al. Global trends in molecular epidemiology of HIV-1 during 2000– 2007. AIDS, v.25, n.5, p.679-689, Mar. 2011. | pt_BR |
ISSN | 0269-9370 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30071 | |
Description | AUTHORS - Joris Hemelaar1,*, Eleanor Gouws2, Peter D. Ghys2, Saladin Osmanov3, and WHO-UNAIDS Network for HIV Isolation and Characterisation. AFFILIATIONS - 1Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom 2Epidemiology and Analysis Division, UNAIDS, Geneva, Switzerland 3WHO-UNAIDS HIV Vaccine Initiative, World Health Organisation, Geneva, Switzerland. | pt_BR |
Language | eng | pt_BR |
Publisher | Lippincott, Williams & Wilkins | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | HIV | pt_BR |
Subject in Portuguese | Epidemiologia molecular | pt_BR |
Subject in Portuguese | Vacina | pt_BR |
Subject in Portuguese | Subtipo | pt_BR |
Subject in Portuguese | Forma Recombinante Circulante | pt_BR |
Subject in Portuguese | Recombinante | pt_BR |
Title | Global trends in molecular epidemiology of HIV-1 during 2000– 2007 | pt_BR |
Type | Article | pt_BR |
DOI | 10.1097/QAD.0b013e328342ff93 | |
Abstract | Objective—To estimate the global and regional distribution of HIV-1 subtypes and recombinants between 2000 and 2007. Design—Country-specific HIV-1 molecular epidemiology data were combined with estimates of the number of HIV-infected people in each country. Method—Cross-sectional HIV-1 subtyping data were collected from 65913 samples in 109 countries between 2000 and 2007. The distribution of HIV-1 subtypes in individual countries was weighted according to the number of HIV-infected people in each country to generate estimates of regional and global HIV-1 subtype distribution for the periods 2000–2003 and 2004–2007. Results—Analysis of the global distribution of HIV-1 subtypes and recombinants in the two time periods indicated a broadly stable distribution of HIV-1 subtypes worldwide with a notable increase in the proportion of circulating recombinant forms (CRFs), a decrease in unique recombinant forms (URFs), and an overall increase in recombinants. In 2004–2007, subtype C accounted for nearly half (48%) of all global infections, followed by subtypes A (12%) and B (11%), CRF02_AG (8%), CRF01_AE (5%), subtype G (5%) and D(2%). Subtypes F, H, J and K together cause fewer than 1% of infections worldwide. Other CRFs and URFs are each responsible for 4% of global infections, bringing the combined total of worldwide CRFs to 16% and all recombinants (CRFs plus URFs) to 20%. Conclusions—The global and regional distributions of individual subtypes and recombinants are broadly stable, although CRFs may play an increasing role in the HIV pandemic. The global diversity of HIV-1 poses a formidable challenge to HIV vaccine development. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Múltiplas Instituições - ver em Notas | pt_BR |
Subject | Circulating Recombinant Form (CRF( | pt_BR |
Subject | HIV | pt_BR |
Subject | subtype | pt_BR |
Subject | recombinant | pt_BR |
Subject | molecular epidemiology | pt_BR |
Embargo date | 2030-01-01 | |