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TIMING OF ANTIRETROVIRAL THERAPY FOR HIV-1 INFECTION AND TUBERCULOSIS
Havlir, Diane V. et al. | Date Issued: 2011
Author
Havlir, Diane V.
Kendall, Michelle A.
Ive, Prudence
Kumwenda, Johnstone
Swindells, Susan
Qasba, Sarojini S.
Luetkemeyer, Anne F.
Hogg, Evelyn
Rooney, James F.
Wu, Xingye
Hosseinipour, Mina C.
Lalloo, Umesh
Veloso, Valdiléa G.
Some, Fatma F.
Kumarasamy, N.
Padayatchi, Nesri
Santos, Breno R.
Reid, Stewart
Hakim, James
Mohapi, Lerato
Mugyenyi, Peter
Sanchez, Jorge
Lama, Javier R.
Pape, Jean W.
Sanchez, Alejandro
Asmelash, Aida
Moko, Evans
Sawe, Fred
Andersen, Janet
Sanne, Ian
AIDS Clinical Trials Group Study A5221
Affilliation
University of San Francisco. San Francisco, CA, USA.
Harvard School of Public Health. Boston, MA, USA.
University of Witwatersrand. Johannesburg, South Africa.
College of Medicine Johns Hopkins Project. Blantyre, Malawi.
University of Nebraska. Omaha, NE, USA.
National Institutes of Health. Bethesda, MD, USA.
University of San Francisco. San Francisco, CA, USA.
Social & Scientific Systems. Silver Spring, MD, USA.
Gilead Sciences. Foster City, CA, USA.
Harvard School of Public Health. Boston, MA, USA.
University of North Carolina Project. Kamuzu Central Hospital. Lilongwe, Malawi.
University of KwaZulu-Natal. Durban, South Africa.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Moi University Faculty of Health Sciences. Eldoret, Kenya.
YRG Centre for AIDS Research and Education. Voluntary Health Services. Chennai, India.
CAPRISA e Thekwini Clinical Research Site. Durban, South Africa.
Hospital Nossa Senhora da Conceição. Porto Alegre, RS, Brasil.
Centre for Infectious Disease Research in Zambia HIV/AIDS Clinical Trials Unit. Lusaka, Zambia.
Parirenyatwa CRS. Harare, Zimbabwe.
Chris Hani Baragwanath Hospital ACTG CRS. Soweto, South Africa.
Joint Clinical Research Centre. Kampala, Uganda.
Asociacion Civil Impacta Salud y Educacion – IMPACTA. Miraflores CRS. Lima, Perú.
Investigaciones Medicas en Salud - INMENSA. Lince CRS. Lima, Perú.
Les Centres GHESKIO. Port-au-Prince, Haiti.
University of Southern California CRS. Los Angeles, CA, USA.
Botswana Harvard Aids Institute CRSs. Gaborone and Molepolole, Botswana.
Botswana Harvard Aids Institute CRSs. Gaborone and Molepolole, Botswana.
Kenya Medical Research Institute./ Walter Reed Project and U.S. Military HIV Research Program. Kericho, Kenya.
Harvard School of Public Health. Boston, MA, USA.
University of Witwatersrand. Johannesburg, South Africa.
Abstract
Antiretroviral therapy (ART) is indicated during tuberculosis treatment in patients infected with human immunodeficiency virus type 1 (HIV-1), but the timing for the initiation of ART when tuberculosis is diagnosed in patients with various levels of immune compromise is not known.
Citation
HAVLIR, D. V. et al. Timing of antiretroviral therapy for HIV-1 infection and tuberculosis. New England Journal of Medicine, v. 365, n. 16, p. 1482-1491, 2011.
DOI
10.1056/NEJMoa1013607
ISSN
0028-4793
Notes
AIDS Clinical Trials Group Study A5221 collaborators: Jones L, Suckow C, Martinez A, Nicotera J, Mensah-King M, Anthony P, Aweeka F, Barlow N, Behm T, Campos P, Firnhaber C, Supparatpinyo K, Leger P, Martinson F, Salata R, Zolopa A, Purcelle E, Smith BA, Near K, DeCarlo E, Mahgoub S, Parker R, Komarow L, Asmuth D, Hanekom W, Walawander A, Corbett A, John MA, van der Horst C, Kondo P, Gutzman H, Hunter H, Pfister S, Poblenz M, Shaw A, Sprenger H, Appiah K.