| Author | Cabral, M. M. O. | |
| Author | Barbosa Filho, J. M. | |
| Author | Maia, G. L. A. | |
| Author | Chaves, M. C. O. | |
| Author | Braga, M.V. | |
| Author | Souza, W. de | |
| Author | Soares, R. O. A. | |
| Access date | 2018-12-04T10:02:21Z | |
| Available date | 2018-12-04T10:02:21Z | |
| Document date | 2010 | |
| Citation | CABRAL, M. M. O. et al. Neolignans from plants in northeastern Brazil (Lauraceae) with activity against Trypanosoma cruzi. Experimental Parasitology, v.124, p.319–324, Nov. 2010. | pt_BR |
| ISSN | 0014-4894 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30374 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Lignanas | pt_BR |
| Subject in Portuguese | Quimioterapia | pt_BR |
| Subject in Portuguese | Nordeste do Brazil | pt_BR |
| Subject in Portuguese | Plantas | pt_BR |
| Title | Neolignans from plants in northeastern Brazil (Lauraceae) with activity against Trypanosoma cruzi | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.exppara.2009.11.007 | |
| Abstract | Trypanosoma cruzi is the ethiological agent for Chagas disease in Latin America. This study aimed to test the trypanocidal effect of licarin A and burchellin isolated from plants in northeastern Brazil. These neolignans were tested on T. cruzi and on peritoneal macrophages, to evaluate drug toxicity. Epimastigote growth was inhibited in 45% with licarin A and 20% with burchellin with an IC(50)/96 h of 462.7 microM and 756 microM, respectively. Epimastigotes treated with licarin A presented swollen mitochondria and disorganized mitochondrial cristae, kDNA and Golgi complex. When treated with burchellin, they presented enormous autophagosomes and chromatin disorganization. Licarin A and burchellin were able to induce trypomastigote death with IC(50)/24 h of 960 microM and 520 microM, respectively. Although licarin A presented an IC(50) for trypomastigotes higher than for epimastigotes, both substances acted as therapeutic trypanocidal agents, because they were able to kill parasites without affecting macrophages. Due to our results, burchellin and licarin A need to be further analysed to observe if they may be used as alternative blood additive prophylaxis against Chagas disease, since it has been established that blood transfusion is an important mechanism in the transmission process. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Diptera. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Departamento de Tecnologia Farmacêutica. João Pessoa, PB, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Departamento de Tecnologia Farmacêutica. João Pessoa, PB, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Departamento de Tecnologia Farmacêutica. João Pessoa, PB, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ecoepidemiologia da Doença de Chagas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Ultraestrutura Celular Hertha Meyer. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Nectandra glabrescens | pt_BR |
| Subject | Ocotea cymbarum | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Licarin A | pt_BR |
| Subject | Burchellin | pt_BR |
| Subject | Neolignans | pt_BR |
| Subject | Chemotherapy | pt_BR |
| Subject | northeastern Brazil | pt_BR |
| Embargo date | 2030-01-01 | |
