Please use this identifier to cite or link to this item:
Type
ArticleCopyright
Restricted access
Embargo date
2030-01-01
Collections
- INI - Artigos de Periódicos [3504]
- IOC - Artigos de Periódicos [12821]
Metadata
Show full item record
SEPSIS-ASSOCIATED ENCEPHALOPATHY: A MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY STUDY
Infecção
Sistema nervoso central
Delírio
Barreira hematoencefalica
Author
Affilliation
Abstract
Brain dysfunction is frequently observed in sepsis as a consequence of changes in cerebral structure and metabolism, resulting in worse outcome and reduced life-quality of surviving patients. However, the mechanisms of sepsis-associated encephalopathy development and a better characterization of this syndrome in vivo are lacking. Here, we used magnetic resonance imaging (MRI) techniques to assess brain morphology and metabolism in a murine sepsis model (cecal ligation and puncture, CLP). Sham-operated and CLP mice were subjected to a complete MRI session at baseline, 6 and 24h after surgery. Accumulation of vasogenic edematic fluid at the base of the brain was observed in T2-weighted image at 6 and 24h after CLP. Also, the water apparent diffusion coefficients in both hippocampus and cortex were decreased, suggesting a cytotoxic edema in brains of nonsurvival septic animals. Moreover, the N-acetylaspartate/choline ratio was reduced in brains of septic mice, indicating neuronal damage. In conclusion, noninvasive assessment by MRI allowed the identification of new aspects of brain damage in sepsis, including cytotoxic and vasogenic edema as well as neuronal damage. These findings highlight the potential applications of MRI techniques for the diagnostic and therapeutic studies in sepsis.
Keywords in Portuguese
InflamaçãoInfecção
Sistema nervoso central
Delírio
Barreira hematoencefalica
Share