Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/30435
Title: Hepatitis C virus infection in Brazilian long-distance truck drivers
Authors: Freitas, Nara R.
Teles, Sheila A.
Matos, Marcos A.
Lopes, Carmen L. R.
Reis, Nádia R. S.
Espírito-Santo, Márcia P.
Lampe, Elisabeth
Martins, Regina M. B.
Affilliation: Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiás, Brasil / Universidade Federal de Goiás. Goiás, Brasil.
Universidade Federal de Goiás. Goiás, Brasil.
Universidade Federal de Goiás. Goiás, Brasil.
Universidade Federal de Goiás. Goiás, Brasil.
Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiás, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiás, Brasil
Abstract: Hepatitis C virus (HCV) infection is a global public health problem. Long-distance truck drivers live apart from their family for long periods of time, a lifestyle that favors at-risk behaviors such as unprotected sex with multiple partners and illicit drug use. As data concerning HCV infection in this population are still rare, this paper aims to investigate the prevalence, genotypes/subtypes, and the factors associated with HCV infection in long-distance truck drivers in Brazil. A cross-sectional survey was carried out with 641 Brazilian long-truck drivers who were recruited at a major truck stop located at kilometer 1,296 of the BR-153 highway, which is considered to be one of the longest roads in Brazil. All individuals were interviewed, and their serum samples were tested for the presence of antibodies to HCV (anti-HCV) by ELISA and immunoblot. Anti-HCV positive samples were tested for HCV RNA by PCR amplification of the 5′ NC and NS5B regions and were genotyped using the LiPA assay and nucleotide sequencing, respectively. Factors associated with HCV infection were identified with logistic regression. The prevalence of HCV infection was 1.4% (95% CI: 0.7-2.8). History of blood transfusion, sharing of personal hygiene tools, illicit drug use and HBV status were factors independently associated with HCV infection in the study population. HCV RNA was detected in 8/9 anti-HCV positive samples, in which genotypes 1 (n = 3), 2 (n = 2), and 3 (n = 3) were determined by LiPA. Using phylogenetic tree analysis of the NS5B region, subtypes 1a (n = 1), 1b (n = 2), 2b (n = 2) and 3a (n = 3) were identified. These data show that the prevalence of HCV infection among Brazilian truck drivers was similar to that observed for the general population. History of blood transfusion, sharing of personal hygiene tools, illicit drug use and HBV status were predictors of HCV infection. The HCV genotypes/subtypes identified in the study population are consistent with those circulating in Brazil.
Keywords: Hepatitis C virus infection
Brazil
long-distance truck drivers
keywords: Vírus da Hepatite C
Infecção
Brasill
caminhoneiros de longa distância
Issue Date: 2010
Publisher: BMC
Citation: FREITAS, Nara R, et al. Hepatitis C virus infection in Brazilian long-distance truck drivers Virology Journal, v.7:205, 6p, 2010.
ISSN: 1743-422X
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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