| Author | Lima, Lyana Rodrigues Pinto | |
| Author | Araújo, Nathália Alves de | |
| Author | Guterres, Alexandro | |
| Author | Pilotto, José Henrique | |
| Author | Niel, Christian | |
| Author | Paula, Vanessa Salete de | |
| Access date | 2018-12-13T10:15:27Z | |
| Available date | 2018-12-13T10:15:27Z | |
| Document date | 2018 | |
| Citation | LIMA, Lyana Rodrigues Pinto; et al. Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects. Mem Inst Oswaldo Cruz, v..113, n.12, e180328, 4p, 2018. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30558 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Brasil | pt_BR |
| Subject in Portuguese | Co-infecção | pt_BR |
| Subject in Portuguese | glycoprotein B | pt_BR |
| Subject in Portuguese | HSV-2 | pt_BR |
| Subject in Portuguese | HIV | pt_BR |
| Title | Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects | pt_BR |
| Type | Article | |
| Abstract | BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified
into two clades.
OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women.
METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B
(gB) coding regions.
FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women,
showed a notable genetic divergence (> 1%).
MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and
HIV/HHV-2 coinfection need to be investigated.. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | clade | pt_BR |
| Subject | Co-infection | pt_BR |
| Subject | glycoprotein B | pt_BR |
| Subject | HSV-2 | pt_BR |
| Subject | HIV | pt_BR |
| e-ISSN | 1678-8060 | |
