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NOVEL VARIANTS OF HUMAN HERPESVIRUS 2 FROM BRAZILIAN HIV-1 COINFECTED SUBJECTS
Lima, Lyana Rodrigues Pinto et al. | Date Issued: 2018
Author
Lima, Lyana Rodrigues Pinto
Araújo, Nathália Alves de
Guterres, Alexandro
Pilotto, José Henrique
Niel, Christian
Paula, Vanessa Salete de
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.
Abstract
BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated..
Keywords in Portuguese
Brasil
Co-infecção
glycoprotein B
HSV-2
HIV
 
Keywords
Brazil
clade
Co-infection
glycoprotein B
HSV-2
HIV
 
Publisher
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Citation
LIMA, Lyana Rodrigues Pinto; et al. Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects. Mem Inst Oswaldo Cruz, v..113, n.12, e180328, 4p, 2018.
ISSN
0074-0276