Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/30558
Title: Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects
Authors: Lima, Lyana Rodrigues Pinto
Araújo, Nathália Alves de
Guterres, Alexandro
Pilotto, José Henrique
Niel, Christian
Paula, Vanessa Salete de
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.
Abstract: BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated..
Keywords: Brazil
clade
Co-infection
glycoprotein B
HSV-2
HIV
keywords: Brasil
Co-infecção
glycoprotein B
HSV-2
HIV
Issue Date: 2018
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Citation: LIMA, Lyana Rodrigues Pinto; et al. Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects. Mem Inst Oswaldo Cruz, v..113, n.12, e180328, 4p, 2018.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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