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AutorCaria, Alex Cleber Improta
AutorNonaka, Carolina Kymie Vasques
AutorPereira, Ciro Silveira
AutorSoares, Milena Botelho Pereira
AutorMacambira, Simone Garcia
AutorSouza, Bruno Solano de Freitas
Fecha de acceso2018-12-18T12:11:11Z
Fecha de disponibilización2018-12-18T12:11:11Z
Fecha de publicación2018
ReferenciaCARIA, A. C. I., et al. Exercise training-Induced changes in MicroRNAs: Beneficial regulatory effects in hypertension, type 2 diabetes, and obesity. International Journal of Molecular Sciences, v. 19, p. 3608, 2018.pt_BR
ISSN1661-6596pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/30650
Idiomaengpt_BR
EditorMDPIpt_BR
Derechos de autoropen accesspt_BR
Palabras clave en PortuguésMicroRNAspt_BR
Palabras clave en PortuguésHipertensão arterial sistêmicapt_BR
Palabras clave en PortuguésDiabetes mellitus tipo 2pt_BR
Palabras clave en PortuguésObesidadept_BR
Palabras clave en PortuguésTreino de exercíciospt_BR
Palabras clave en PortuguésMicroRNApt_BR
TítuloExercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesitypt_BR
Tipo del documentoArticlept_BR
DOI10.3390/ijms19113608
Resumen en InglésMicroRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally. They are involved in the regulation of physiological processes, such as adaptation to physical exercise, and also in disease settings, such as systemic arterial hypertension (SAH), type 2 diabetes mellitus (T2D), and obesity. In SAH, microRNAs play a significant role in the regulation of key signaling pathways that lead to the hyperactivation of the renin-angiotensin-aldosterone system, endothelial dysfunction, inflammation, proliferation, and phenotypic change in smooth muscle cells, and the hyperactivation of the sympathetic nervous system. MicroRNAs are also involved in the regulation of insulin signaling and blood glucose levels in T2D, and participate in lipid metabolism, adipogenesis, and adipocyte differentiation in obesity, with specific microRNA signatures involved in the pathogenesis of each disease. Many studies report the benefits promoted by exercise training in cardiovascular diseases by reducing blood pressure, glucose levels, and improving insulin signaling and lipid metabolism. The molecular mechanisms involved, however, remain poorly understood, especially regarding the participation of microRNAs in these processes. This review aimed to highlight microRNAs already known to be associated with SAH, T2D, and obesity, as well as their possible regulation by exercise training.pt_BR
AfiliaciónFederal University of Bahia. Multicentric Program of Post-Graduate in Biochemistry and Molecular Biology. Salvador, BA, Brazil / São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil.pt_BR
AfiliaciónSão Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.pt_BR
AfiliaciónSão Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil.pt_BR
AfiliaciónSão Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil.pt_BR
AfiliaciónFederal University of Bahia. Multicentric Program of Post-Graduate in Biochemistry and Molecular Biology. Salvador, BA, Brazil / São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Bahia. Health Sciences Institute. Department of Biochemistry and Biophysics. Salvador, BA, Brazil.pt_BR
AfiliaciónSão Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil.pt_BR
Palavras clave en InglêsMicroRNAspt_BR
Palavras clave en InglêsSystemic arterial hypertensionpt_BR
Palavras clave en InglêsType 2 diabetes mellituspt_BR
Palavras clave en InglêsObesitypt_BR
Palavras clave en InglêsExercise trainingpt_BR
Palavras clave en InglêsMicroRNApt_BR


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