| Author | Batista, Denise da Gama Jaén | |
| Author | Silva, Patrícia Bernardino da | |
| Author | Lachter, Daniela R. | |
| Author | Silva, Renata S. | |
| Author | Aucelio, Ricardo Q. | |
| Author | Louro, Sonia R. W. | |
| Author | Beraldo, Heloisa | |
| Author | Soeiro, Maria de Nazaré C. | |
| Author | Teixeira, Letícia R. | |
| Access date | 2018-12-18T13:10:08Z | |
| Available date | 2018-12-18T13:10:08Z | |
| Document date | 2010 | |
| Citation | BATISTA, Denise da Gama Jaén; et al. Manganese(II) complexes with N4-methyl-4-nitrobenzaldehyde, N4-methyl-4-nitroacetofenone, and N4-methyl-4-nitrobenzophenone thiosemicarbazone: Investigation of in vitro activity against Trypanosoma cruzi. Polyhedron, v.29, p.2232–2238, Apr. 2010. | pt_BR |
| ISSN | 0277-5387 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30652 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Quimioterapia | pt_BR |
| Title | Manganese(II) complexes with N4-methyl-4-nitrobenzaldehyde, N4-methyl-4-nitroacetofenone, and N4-methyl-4-nitrobenzophenone thiosemicarbazone: Investigation of in vitro activity against Trypanosoma cruzi | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.poly.2010.04.023 | |
| Abstract | Thiosemicarbazones are known to be active against different pathogenic microorganisms including Trypanosoma
cruzi, the etiological agent of Chagas disease. In the search for new therapeutic drugs against
this illness, the complexes [Mn(H4NO2Fo4M)2Cl2] (1), [Mn(H4NO2Ac4M)2Cl2] (2) and [Mn(H4NO2
Bz4M)2Cl2] (3) of N4-methyl-4-nitrobenzaldehyde thiosemicarbazone (H4NO2Fo4M), N4-methyl-4-nitroacetophenone
thiosemicarbazone (H4NO2Ac4M) and N4-methyl-4-nitrobenzophenone thiosemicarbazone
(H4NO2Bz4M) were obtained and screened in vitro against bloodstream and intracellular forms of
T. cruzi. H4NO2Fo4M, H4NO2Ac4M and their Mn(II) complexes displayed poor effect on bloodstream trypomastigotes,
with IC50 values ranging from 68 to >200 lM. However, although H4NO2Bz4M was also not
active, its corresponding Mn(II) complex presented high effect on this T. cruzi form, with an IC50 value of
19 lM. The effect of complex (3), against trypomastigotes of T. cruzi supports further in vitro as well as
in vivo studies. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Química. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Química. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Química. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Física. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Chagas Disease | pt_BR |
| Subject | Chemotherapy | pt_BR |
| Subject | Nitro-thiosemicarbazones | pt_BR |
| Subject | Mn(II) complexes | pt_BR |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
