Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/30717
Title: Polymorphisms in TLR4 and TNFA and Risk of Mycobacterium tuberculosis Infection and Development of Active Disease in Contacts of Tuberculosis Cases in Brazil: A Prospective Cohort Study
Authors: Cubillos-Angulo, Juan Manuel
Arriaga, María Belen
Silva, Elisângela C.
Müller, Beatriz de Lima Alessio
Ramalho, Daniela Maria de Paula
Fukutani, Kiyoshi Ferreira
Miranda, Pryscila Fernandes Campino
Moreira, Adriana S. R.
Ruffino Netto, Antonio
Silva, Jose Roberto Lapa e
Sterling, Timothy R.
Kritski, Afrânio Lineu
Oliveira, Martha M.
Andrade, Bruno de Bezerril
Affilliation: Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.
Universidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil / State University of North Fluminense Darcy Ribeiro. Recognize the Biology Laboratory. Center of Bioscience and Biotechnology. Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Osvaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.
Universidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil
Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.
Universidade Federal do Rio de Janeiro. Faculdade de Medicina e Complexo Hospitalar. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil.
Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, Tennessee, USA.
Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, Tennessee, USA / University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Wellcome Centre for Infectious Disease Research in Africa. Cape Town, South Africa / Universidade Salvador. Laureate University. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Abstract: Background: The role of genetic polymorphisms in latent tuberculosis (TB) infection and progression to active TB is not fully understood. Methods: We tested the single nucleotide polymorphisms (SNPs) rs5743708 (TLR2), rs4986791 (TLR4), rs361525 (TNFA), rs2430561 (IFNG) rs1143627 (IL1B) as risk factors for tuberculin skin test (TST) conversion or development of active TB in contacts of active TB cases. Contacts of microbiologically confirmed pulmonary TB cases were initially screened for longitudinal evaluation up to 24 months, with clinical examination and serial TST, between 1998 and 2004 at a referral center in Brazil. Data and biospecimens were collected from 526 individuals who were contacts of 177 active TB index cases. TST conversion was defined as ≥5 f TST result (0 mm) at baseline or month 4 visit. Independent associations were tested using logistic regression models.
Keywords: Single nucleotide polymorphism
Tuberculin skin test
Mycobacterium tuberculosis
Tumor necrosis factor
Toll-like receptor
Issue Date: 2018
Publisher: Oxfor University Press
Citation: CUBILLOS-ANGULO, J. M. et al. Polymorphisms in TLR4 and TNFA and risk of mycobacterium tuberculosis infection and development of active disease in contacts of tuberculosis cases in Brazil: A prospective cohort study. Clinical Infectious Disease, p. 1-35, Nov. 2018.
DOI: 10.1093/cid/ciy1001
Copyright: open access
Revised document: Não
Publication status: Não Publicado
Appears in Collections:CDTS - Artigos de Periódicos
IOC - Preprint
BA - IGM - Preprint

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