| Author | Nicol, Alcina F. | |
| Author | Andrade, Cecilia Vianna de | |
| Author | Gomes Jr., Saint Clair | |
| Author | Brusadelli, Marion G. | |
| Author | Lodin, Hannah M. | |
| Author | Wells, Susanne I. | |
| Author | Nuovo, Gerard J. | |
| Access date | 2018-12-27T13:16:45Z | |
| Available date | 2018-12-27T13:16:45Z | |
| Document date | 2019 | |
| Citation | NICOL, Alcina F. et al. The distribution of novel biomarkers in carcinoma-in-situ, microinvasive, and squamous cell carcinoma of the uterine cervix. Annals of Diagnostic Pathology, v. 38, p. 115-122, 2019. | pt_BR |
| ISSN | 1092-9134 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30792 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | |
| Title | The distribution of novel biomarkers in carcinoma-in-situ, microinvasive, and squamous cell carcinoma of the uterine cervix | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.anndiagpath.2018.12.001 | |
| Abstract | Importin-β, exportin-5, p16, Ki-67, Mcl1, PDL1, and cFLIP are each over-expressed in the majority of CIN 1
lesions. These biomarkers, plus HPV E6/E7 RNA, were analyzed in carcinoma-in-situ (CIS), microinvasive, and squamous cell carcinoma (SCC) of the uterine cervix and cervical carcinoma cell lines. Only p16 and Ki-67
continued to be over-expressed in CIS, with a concomitant marked increase in E6/E7 RNA. There was a highly
significant increase in PDL1 expression and decrease in Ki-67 (each p < 0.001) in microinvasive cancer compared to CIS whereas p16 and E6/E7 remained stable. As the lesion progressed to SCC, p16 and E6/E7 RNA remained strongly overexpressed with a concomitant over expression of importin-β and Ki67. HPV positive Caski cells showed significant elevations of p16, importin-β, exportin-5 and PDL1 compared to the HPV negative cervical cancer cell line C33A, consistent with viral induction of these biomarkers. The data suggest that PDL1 may be a useful biomarker to differentiate CIS from microinvasive cancer and, thus, anti-PDL1 therapy may inhibit the progression of CIS to the invasive stage. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. National Institute of Infectious Diseases Evandro Chagas. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. National Institute of Health of Women, Children, and Adolescents, Fernandes Figueira. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Oswaldo Cruz Foundation. National Institute of Health of Women, Children, and Adolescents, Fernandes Figueira. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Cincinnati Children's Hospital Medical Center. Division of Oncology, Cancer and Blood Diseases Institute. Cincinnati, OH, USA. | pt_BR |
| Affilliation | Cincinnati Children's Hospital Medical Center. Division of Oncology, Cancer and Blood Diseases Institute. Cincinnati, OH, USA. | pt_BR |
| Affilliation | Cincinnati Children's Hospital Medical Center. Division of Oncology, Cancer and Blood Diseases Institute. Cincinnati, OH, USA. | pt_BR |
| Affilliation | The Ohio State University Comprehensive Cancer Center. Columbus, OH, USA / Phylogeny Inc, Powell. OH, USA. | pt_BR |
| Subject | Cervical cancer | pt_BR |
| Subject | Microinvasive | pt_BR |
| Subject | PDL-1 | pt_BR |
| Subject | Biomarkers | pt_BR |
| Embargo date | 2020-01-31 | |
