Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/30990
Title: Therapeutic uses for Angiotensin-(1-7)
Authors: Machado-Silva, Alice
Passos-Silva, Danielle
Santos, Robson Augusto
Sinisterra, Rubén Dario
Affilliation: Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia e Biofísica. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil.
Abstract: Angiotensin-(1-7) is a key component of the Renin-Angiotensin System, which can counter-regulate several deleterious effects caused by angiotensin II. Due to the potential for therapeutic use, several of its actions are specifically described in patents. Areas covered: In this review, the authors describe a plethora of therapeutic uses for Angiotensin-(1-7), claimed and supported by experimental evidence in patent documents and applications. Expert opinion: The clinical potential of Angiotensin-(1-7) as a therapeutic agent to treat several pathologies is evidenced by the variety of patents and clinical trials involving this peptide. Cancer treatment is one of the most advanced therapeutic areas, but clinical studies are also available in several other areas, such as cardiovascular, hematological, transplantation, surgical and medical procedures.
Keywords: Angiotensin (1-7)
Arg0
Mas receptor
PanCyte
TXA-127
RAS
Issue Date: 2016
Publisher: Taylor & Francis Group
Citation: MACHADO-SILVA, A. et al. Therapeutic uses for Angiotensin-(1-7). Expert Opinion on Therapeutic Patents, v. 26, n.6, p. 669-678, 2016.
DOI: 10.1080/13543776.2016.1179283
ISSN: 1744-7674
Copyright: restricted access
Appears in Collections:CDTS - Artigos de Periódicos

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