Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31006
Title: Warfare and defense: The host response to Cryptococcus infection
Authors: Dutra, Fabianno F.
Albuquerque, Priscila C.
Rodrigues, Marcio L.
Fonseca, Fernanda L.
Affilliation: Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goes. Departamento de Imunologia. Laboratório de Inflamação e Imunidade. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goes. Departamento de Microbiologia Geral. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.
Abstract: Cryptococcus neoformans and Cryptococcus gatti are the etiological agents of cryptococcosis, a life-threatening mycosis affecting the central nervous system. Cryptococcal meningoencephalitis is the most fatal mycosis in AIDS patients, resulting almost 200 000 deaths annually. High cost, side effects and drug resistance are constant elements during treatment of cryptococcosis, encouraging the development of novel therapeutic strategies including immunomodulatory protocols. Thereby, to understand how the host responds to Cryptococcus is essential. In this review, we discuss the immune response against Cryptococcus and immunoevasion strategies.
Keywords: Cryptococcus gattii
Cryptococcal infection
Cryptococcus neoformans
Host immunity
Immune response
Macrophage
Issue Date: 2018
Publisher: Elsevier
Citation: DUTRA, F. F. et al. Warfare and defense: The host response to Cryptococcus infection. Fungal Biology Reviews, v. 32, p. 35-51, 2018.
DOI: 10.1016/j.fbr.2017.09.002
ISSN: 1749-4613
Copyright: restricted access
Appears in Collections:CDTS - Artigos de Periódicos

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