Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31029
Title: Visual function in infants with antenatal Zika virus exposure
Authors: Zin, Andrea A.
Tsui, Irena
Rossetto, Julia D.
Gaw, Stephanie L.
Neves, Luiza M.
Zin, Olivia A.
Haefeli, Lorena
Silveira Filho, Joel Carlos Barros
Adachi, Kristina
Pone, Marcos Vinicius da Silva
Pone, Sheila Moura
Molleri, Natalia
Pereira Jr., José Paulo
Belfort, Rubens
Arumugaswami, Vaithilingaraja
Vasconcelos, Zilton
Brasil, Patricia
Nielsen-Saines, Karin
Moreira, Maria Elisabeth Lopes
Affilliation: Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
University of California Los Angeles. Los Angeles, CA, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
University of California, San Francisco. Department of Obstetrics, Gynecology & Reproductive Sciences. Division of Maternal-Fetal Medicine. San Francisco, CA, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil / Hospital Federal dos Servidores do Estado, Rio de Janeiro, RJ, Brasil.
Hospital Federal dos Servidores do Estado, Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Universidade Unigranrio. Duque de Caxias, RJ, Brasil.
University of California Los Angeles. Los Angeles, CA, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Universidade Federal de São Paulo, São Paulo, SP, Brasil.
University of California Los Angeles. Los Angeles, CA, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
University of California Los Angeles. Los Angeles, CA, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Abstract: PURPOSE To report the findings of a cross-sectional study of visual function in infants with confirmed or suspected antenatal Zika virus (ZIKV) infection seen at a single referral center in Rio de Janeiro. METHODS Infants were examined following the ZIKV outbreak period at Instituto Fernandes Figueira/FIOCRUZ. Visual function was considered abnormal if an infant could not fix and follow a standardized high-contrast target (10 cm) by 3-6 months of age. Visual function and associations with structural eye abnormalities, central nervous system (CNS) abnormalities, microcephaly, and nystagmus were assessed. Sensitivity and specificity of screening criteria for structural eye abnormalities was assessed. RESULTS A total of 173 infants met inclusion criteria. Abnormal visual function was found in 52 infants (30.0%) and was significantly associated with eye abnormalities (40/52; OR 5 44.2; 95% CI, 16.6-117.6), CNS abnormalities (50/52; OR 5 64.0; 95% CI, 14.7-277.6), microcephaly (44/52; OR 5 31.5; 95% CI, 12.7-77.8), and nystagmus (26/52; OR 5 120.0; 95% CI, 15.6-924.5). Using microcephaly as screening criteria for the detection of eye abnormalities provided a sensitivity of 88.9% (95% CI, 76.0-96.3) and specificity of 82.8% (95% CI, 75.1-88.9). Using both abnormal visual function and microcephaly increased sensitivity to 100% (95% CI, 92.1-100.0) and decreased specificity to 80.5% (95% CI, 72.5-86.9). CONCLUSIONS Infants with suspected antenatal ZIKV infection and reduced visual function should be referred to an ophthalmologist. Visual function assessments are helpful in screening for antenatal ZIKV exposure in resource-limited settings and can identify infants who may benefit from visual habilitation.
Keywords: Zika virus
Infants
Visual function
Issue Date: 2018
Publisher: Elsevier
Citation: ZIN, Andrea A. et al. Visual function in infants with antenatal Zika virus exposure. Journal of AAPOS, v. 22, n. 6, p. 452-456, Dec. 2018.
DOI: 10.1016/j.jaapos.2018.07.352
ISSN: 1091-8531
Copyright: restricted access
Appears in Collections:IFF - Artigos de Periódicos
INI - Artigos de Periódicos

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