Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31052
Title: Autoimmune thrombocytopenia related to chronic hepatitis C virus infection
Authors: Almeida, A. J. de
Magalhães, M. Campos de
Antonietti, C. L.
Mello, C. E. Brandão
Silva, M. L. P. da
Oliveira, R. V. de
Espírito Santo, M. P. do
Yoshida, C. F. T.
Lampe, Elisabete
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Gaffreé Guinle. Departamento de Medicina Geral. Clínica Médica B. Unidade de Hematologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Universitário Gaffreé Guinle. Departamento de Medicina Geral. Clínica Médica B. Unidade de Hematologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Escola de Medicina e Cirurgia. Hospital Universitário Gaffreé Guinle. Departamento de Medicina Geral. Clínica Médica B. Unidade de Hematologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Escola de Medicina e Cirurgia. Hospital Universitário Gaffreé Guinle. Departamento de Medicina Geral. Clínica Médica A. Unidade de Doenças Hepáticas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Abstract: Since the identification of hepatitis C virus (HCV) in 1989 as a causative agent for a number of the extrahepatic alterations related to HCV infection an underlying immune mediated pathogenetic mechanism has been postulated. HCV-associated thrombocytopenia may be considered complex and multifactorial in origin, since different mechanisms have been implicated in its pathophysiology. With respect to autoimmune thrombocytopenia in chronic HCV infection, the detection of specific antibodies against platelet glycoproteins have been reported only in a few studies, but no systematic study has been carried out. We examined the clinical, laboratory, and virological characteristics of a case series of 10 patients with autoimmune thrombocytopenia (platelet count ,150.06109/L) related to chronic HCV infection. Cases, six males and four females, aged 57.1¡12.6 years, presented high titers of antibodies against platelet glycoprotein (GP) IIb/IIIa, GP Ia/IIa, and/or GP Ib/IX, and no other mechanism involved in the pathogenesis of HCV-associated thrombocytopenia was identified. Furthermore, cases were not associated with particular HCV genotype. Complete platelet response was observed in two patients treated with pegylated interferon plus ribavirin, and partial platelet response was seen in two patients treated with anti-D Ig and one patient treated with corticosteroids. These findings indicate that an autoimmune mechanism may play a role in the pathogenesis of HCV-associated thrombocytopenia in a proportion of these patients.
Keywords: Autoimmune thrombocytopenia
Chronic hepatitis C
HCV
Platelets
keywords: Hepatite C crônica
Trombocitopenia autoimune
Plaquetas
Vírus da hepatite C
Issue Date: 2009
Publisher: Taylor & Francis
Citation: ALMEIDA, A. J. de et al. Autoimmune thrombocytopenia related to chronic hepatitis C virus infection. Hematology, v. 14, n. 1, p. 49-58, 2009.
DOI: 10.1179/102453309X385106
ISSN: 1607-8454
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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