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2030-01-01
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ALTERED STEROL PROFILE INDUCED IN LEISHMANIA AMAZONENSIS BY A NATURAL DIHYDROXYMETHOXYLATED CHALCONE
Santos, Eduardo Caio Torres et al. | Date Issued: 2009
Author
Santos, Eduardo Caio Torres
Santos, Maria Isabel Sampaio
Buckner, Frederick S.
Yokoyama, Kohei
Gelb, Michael
Urbina, Julio A.
Bergmann, Bartira Rossi
Affilliation
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil.
University of Washington. Department of Medicine. Seattle, WA, USA.
University of Washington. Department of Chemistry. Seattle, WA, USA.
University of Washington. Department of Chemistry. Seattle, WA, USA.
Instituto Venezoelano de Investigaciones Científicas. Caracas, Venezuela.
Abstract
The effects of the antileishmanial chalcone 2',6'-dihydroxy-4'-methoxychalcone (DMC) on Leishmania amazonensis sterol composition and biosynthesis were investigated to obtain information about the mechanism of growth inhibition by DMC on this parasite.
Keywords in Portuguese
Trypanosoma
metabolismo lipídico
Colesterol
Cetoconazol
 
Keywords
lipid metabolism
cholesterol
ketoconazole
Trypanosoma
 
DeCS
Cetoconazol
Publisher
Oxford University Press
Citation
SANTOS, Eduardo Caio Torres; et al. Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone. Journal of Antimicrobial Chemotherapy, v.63, p.469-472, 2009.
DOI
10.1093/jac/dkn546
ISSN
0305-745