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| Autor | Andrade, Simone Ladeia | |
| Autor | Ferreira, Marcelo Urbano | |
| Autor | Carvalho, Maria Esther de | |
| Autor | Curado, Izilda | |
| Autor | Coura, José Rodrigues | |
| Fecha de acceso | 2019-01-17T13:05:24Z | |
| Fecha de disponibilización | 2019-01-17T13:05:24Z | |
| Fecha de publicación | 2009 | |
| Referencia | ANDRADE, Simone Ladeia; et al. Age-Dependent Acquisition of Protective Immunity to Malaria in Riverine Populations of the Amazon Basin of Brazil. Am. J. Trop. Med. Hyg., v. 80, n. 3, p. 452–459, 2009. | pt_BR |
| ISSN | 0002-9637 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31104 | |
| Idioma | eng | pt_BR |
| Editor | American Society of Tropical Medicine and Hygiene | pt_BR |
| Derechos de autor | open access | |
| Palabras clave en Portugués | Malária | pt_BR |
| Palabras clave en Portugués | Bacia Amazônica | pt_BR |
| Palabras clave en Portugués | Brasil | pt_BR |
| Palabras clave en Portugués | Imunidade | pt_BR |
| Palabras clave en Portugués | Populações ribeirinhas | pt_BR |
| Título | Age-Dependent Acquisition of Protective Immunity to Malaria in Riverine Populations of the Amazon Basin of Brazil | pt_BR |
| Tipo del documento | Article | |
| Resumen en Inglés | Five community-based cross-sectional surveys of malaria morbidity and associated risk factors in remote riverine populations in northwestern Brazil showed average parasite rates of 4.2% (thick-smear microscopy) and 14.4% (polymerase chain reaction [PCR]) in the overall population, with a spleen rate of 13.9% among children 2–9 years of age. Plasmodium vivax was 2.8 times more prevalent than P. falciparum , with rare instances of P. malariae and mixed-species infections confirmed by PCR; 9.6% of asymptomatic subjects had parasitemias detected by PCR. Low-grade parasitemia detected by PCR only was a risk factor for anemia, after controlling for age and other covariates. Although clinical and subclinical infections occurred in all age groups, the risk of infection and disease decreased significantly with increasing age, after adjustment for several covariates in multilevel logistic regression models. These findings suggest that the continuous exposure to hypo- or mesoendemic malaria may induce significant anti-parasite and anti-disease immunity in native Amazonians. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil. | pt_BR |
| Afiliación | Superintendência de Controle de Endemias. Laboratório de Sorologia. São Paulo, SP, Brasil. | pt_BR |
| Afiliación | Superintendência de Controle de Endemias. Laboratório de Sorologia. São Paulo, SP, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Palavras clave en Inglês | Malaria | pt_BR |
| Palavras clave en Inglês | Protective Immunity | pt_BR |
| Palavras clave en Inglês | Riverine Populations | pt_BR |
| Palavras clave en Inglês | Amazon Basin of Brazil | pt_BR |
| e-ISSN | 1476-1645 |
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