Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31104
Title: Age-Dependent Acquisition of Protective Immunity to Malaria in Riverine Populations of the Amazon Basin of Brazil
Authors: Andrade, Simone Ladeia
Ferreira, Marcelo Urbano
Carvalho, Maria Esther de
Curado, Izilda
Coura, José Rodrigues
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ, Brasil.
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.
Superintendência de Controle de Endemias. Laboratório de Sorologia. São Paulo, SP, Brasil.
Superintendência de Controle de Endemias. Laboratório de Sorologia. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ, Brasil.
Abstract: Five community-based cross-sectional surveys of malaria morbidity and associated risk factors in remote riverine populations in northwestern Brazil showed average parasite rates of 4.2% (thick-smear microscopy) and 14.4% (polymerase chain reaction [PCR]) in the overall population, with a spleen rate of 13.9% among children 2–9 years of age. Plasmodium vivax was 2.8 times more prevalent than P. falciparum , with rare instances of P. malariae and mixed-species infections confirmed by PCR; 9.6% of asymptomatic subjects had parasitemias detected by PCR. Low-grade parasitemia detected by PCR only was a risk factor for anemia, after controlling for age and other covariates. Although clinical and subclinical infections occurred in all age groups, the risk of infection and disease decreased significantly with increasing age, after adjustment for several covariates in multilevel logistic regression models. These findings suggest that the continuous exposure to hypo- or mesoendemic malaria may induce significant anti-parasite and anti-disease immunity in native Amazonians.
Keywords: Malaria
Protective Immunity
Riverine Populations
Amazon Basin of Brazil
keywords: Malária
Bacia Amazônica
Brasil
Imunidade
Populações ribeirinhas
Issue Date: 2009
Publisher: American Society of Tropical Medicine and Hygiene
Citation: ANDRADE, Simone Ladeia; et al. Age-Dependent Acquisition of Protective Immunity to Malaria in Riverine Populations of the Amazon Basin of Brazil. Am. J. Trop. Med. Hyg., v. 80, n. 3, p. 452–459, 2009.
ISSN: 0002-9637
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
joseR_coura_etal_IOC_2009.pdf643.82 kBAdobe PDFView/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.