Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31132
Title: Evaluation of the consistency of refills for antiretroviral medications in two hospitals in the state of Rio de Janeiro, Brazil
Authors: Seguy, N.
Diaz, T.
Campos, D. Pereira
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Teixeira, L.
Pillotto, José H.
Affilliation: Centers for Diseases Control and Prevention. Global AIDS Program. Atlanta, GA, USA.
Centers for Diseases Control and Prevention. Global AIDS Program. Atlanta, GA, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Hospital Geral de Nova Iguaçu. Rio de Janeiro, RJ, Brasil.
Abstract: We conducted a retrospective cohort study using pharmacy records to assess the frequency of delay in picking up antiretroviral (ARV) medication refills from the pharmacy and to identify determinants of delay among HIV-infected patients at two Brazilian hospitals. We selected patients who were on ARV therapy before January 2001 at Nova Iguaçu Hospital (NIPRH) (N = 265) and Evandro Chagas (N=424) Clinical Research Institute. We abstracted medical records and pharmacy data using standardised forms and analysed potential associations between delay in refilling medications and patients' demographic characteristics, type of ARV drug regimen and evolution of HIV disease. Sixty-nine patients (26%) had delays in medication refills >1 month at least once in 2001 at NIPRH compared with 140 (33%) patients at IPEC (p=0.052). No factor was found to be associated with having a delay in medication refill >1 month at NIPRH. At IPEC, delays in medication refill >1 month were associated with a median CD4+ T cell count <200/mm(3) versus >500/mm(3) (adjusted odds ratio (AOR) = 3.8; 95% confidence interval (CI) =1.6-8.9) and with dual protease inhibitor-based ARV regimens versus other regimens (AOR = 4.3; 95% CI = 1.9-9.4). In conclusion, rates of delay in medication refills were similar to rates of adherence to ARV therapy found in other studies in Brazil, suggesting that delay in medication refills could be used as a surrogate for adherence. Analysing ARV medication refills can complement self-reported information on adherence.
Keywords: Antiretroviral medications
Brazilian hospitals
Rio de Janeiro
Brazil
Issue Date: 2007
Publisher: Taylor & Francis
Citation: SEGUY, N. et al. Evaluation of the consistency of refills for antiretroviral medications in two hospitals in the state of Rio de Janeiro, Brazil. AIDS Care, v. 19, n. 5, p. 617-625, May 2007.
DOI: 10.1080/09540120600787356
ISSN: 0954-0121
Copyright: restricted access
Appears in Collections:INI - Artigos de Periódicos

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