Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31205
Title: Transmission blocking sugar baits for the control of Leishmania development inside sand flies using environmentally friendly beta-glycosides and their aglycones
Authors: Ferreira, Tainá Neves
Pereira, Daniela Pita
Costa, Samara Graciane
Brazil, Reginaldo Peçanha
Moraes, Caroline Silva
Díaz-Albiter, Hector Manuel
Genta, Fernando Ariel
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Doenças Endêmicas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitarias. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil.
University of Glasgow. Wellcome Centre for Molecular Parasitology. Glasgow, UK / El Colegio de la Frontera Sur. Unidad Villahermosa, Mexico.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil.
Abstract: The sand fly Lutzomyia longipalpis is the main vector of American visceral leishmaniasis, a disease caused by parasites of the genus Leishmania. Adults of this insect feed on blood (females only) or sugar from plant sources, but their digestion of carbohydrates is poorly studied. Beta-glycosides as esculin and amygdalin are plant compounds and release toxic compounds as esculetin and mandelonitrile when hydrolyzed. Beta-glucosidase and trehalase are essential enzymes in sand fly metabolism and participate in sugar digestion. It is therefore possible that the toxic portions of these glycosides, released during digestion, affect sand fly physiology and the development of Leishmania.
Keywords: Lutzomyia longipalpis
Leishmania
Longevity
Beta-glycosides
Trehalase
Beta-glucosidase
Sugar bait
keywords: Lutzomyia longipalpis
Leishmania
beta-Glucosidase
Trealase
Longevidade
Isca de açucar
Issue Date: 2018
Publisher: BMC
Citation: FERREIRA, Tainá Neves; et al. Transmission blocking sugar baits for the control of Leishmania development inside sand flies using environmentally friendly beta-glycosides and their aglycones. Parasites & Vectors, v.11, n.614, 20p, 2018.
DOI: 10.1186/s13071-018-3122-z
ISSN: 1756-3305
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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