Author
Affilliation
Abstract
The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent
discovery of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the
risk of reestablishment of urban YFV transmission in the Americas.We use a suite of
epidemiological, spatial, and genomic approaches to characterize YFV transmission.
We show that the age and sex distribution of human cases is characteristic of sylvatic
transmission. Analysis of YFV cases combined with genomes generated locally reveals an
early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free
areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a
framework for monitoring YFV transmission in real time that will contribute to a global
strategy to eliminate future YFV epidemics.
Publisher
American Association for the Advancement of Science
Citation
FARIA, N. R. et al. Genomic and epidemiological monitoring of yellow fever virus transmission potential. Science, v.361, p.894-899, Aug. 2018.
ISSN
0036-8075
Notes
AUTHORS - N. R. Faria1*†, M. U. G. Kraemer1,2,3*, S. C. Hill1*, J. Goes de Jesus4*, R. S. Aguiar5*,
F. C. M. Iani6,7*, J. Xavier4, J. Quick8, L. du Plessis1, S. Dellicour9, J. Thézé1,
R. D. O. Carvalho7, G. Baele9, C.-H. Wu10, P. P. Silveira5, M. B. Arruda5,
M. A. Pereira6, G. C. Pereira6, J. Lourenço1, U. Obolski1, L. Abade1,11, T. I. Vasylyeva1,
M. Giovanetti4,7, D. Yi12, D. J. Weiss13, G. R. W. Wint1, F. M. Shearer13,
S. Funk14, B. Nikolay15,16, V. Fonseca7,17, T. E. R. Adelino6, M. A. A. Oliveira6,
M. V. F. Silva6, L. Sacchetto7, P. O. Figueiredo7, I. M. Rezende7, E. M. Mello7,
R. F. C. Said18, D. A. Santos18, M. L. Ferraz18, M. G. Brito18, L. F. Santana18,
M. T. Menezes5, R. M. Brindeiro5, A. Tanuri5, F. C. P. dos Santos19, M. S. Cunha19,
J. S. Nogueira19, I. M. Rocco19, A. C. da Costa20, S. C. V. Komninakis21,22, V. Azevedo7,
A. O. Chieppe23, E. S. M. Araujo4, M. C. L. Mendonça4, C. C. dos Santos4,
C. D. dos Santos4, A. M. Mares-Guia4, R. M. R. Nogueira4, P. C. Sequeira4,
R. G. Abreu24, M. H. O. Garcia24, A. L. Abreu25, O. Okumoto25, E. G.Kroon7,
C. F. C. de Albuquerque26, K. Lewandowski27, S. T. Pullan27, M. Carroll28,
T. de Oliveira4,17,29, E. C. Sabino20, R. P. Souza19, M. A. Suchard30,31, P. Lemey9,
G. S. Trindade7, B. P. Drumond7, A.M. B. Filippis4, N. J. Loman8, S. Cauchemez15,16*,
L. C. J. Alcantara4,7*†, O. G. Pybus1*† --- --- AFFILIATIONS - 1Department of Zoology, University of Oxford, Oxford, UK. 2Computational Epidemiology Lab, Boston Children’s Hospital, Boston, MA, USA. 3Department of Pediatrics, Harvard Medical School,
Boston, MA, USA. 4Laboratório de Flavivírus, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil. 5Laboratório de Virologia Molecular, Departamento de Genética, Instituto de Biologia,
Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. 6Laboratório Central de Saúde Pública, Instituto Octávio Magalhães, FUNED, Belo Horizonte, Minas Gerais, Brazil. 7Instituto de
Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. 8Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK. 9Department of
Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium. 10Department of Statistics, University of Oxford, Oxford, UK. 11The Global Health Network, University of Oxford, Oxford,
UK. 12Department of Statistics, Harvard University, Cambridge, MA, USA. 13Malaria Atlas Project, Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK. 14Faculty of
Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK. 15Mathematical Modelling of Infectious Diseases and Center of Bioinformatics, Institut Pasteur,
Paris, France. 16CNRS UMR2000: Génomique Évolutive, Modélisation et Santé, Institut Pasteur, Paris, France. 17KwaZulu-Natal Research, Innovation and Sequencing Platform (KRISP), School of
Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa. 18Secretaria de Estado de Saúde de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. 19Núcleo de
Doenças de Transmissão Vetorial, Instituto Adolfo Lutz, São Paulo, Brazil. 20Instituto de Medicina Tropical e Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. 21Retrovirology
Laboratory, Federal University of São Paulo, São Paulo, Brazil. 22School of Medicine of ABC (FMABC), Clinical Immunology Laboratory, Santo André, São Paulo, Brazil. 23Coordenação de Vigilância
Epidemiológica do Estado do Rio de Janeiro, Rio de Janeiro, Brazil. 24Departamento de Vigilância das Doenças Transmissíveis da Secretaria de Vigilância em Saúde, Ministério da Saúde, Brasília-DF,
Brazil. 25Secretaria de Vigilância em Saúde, Coordenação Geral de Laboratórios de Saúde Pública, Ministério da Saúde, Brasília-DF, Brazil. 26Organização Pan - Americana da Saúde/Organização Mundial da
Saúde - (OPAS/OMS), Brasília-DF, Brazil. 27Public Health England, National Infections Service, Porton Down, Salisbury, UK. 28NIHR HPRU in Emerging and Zoonotic Infections, Public Health England,
London, UK. 29Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa. 30Department of Biostatistics, UCLA Fielding School of Public Health, University of California,
Los Angeles, CA, USA. 31Department of Biomathematics and Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA.
*These authors contributed equally to this work.
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