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Title: Structural and ultrastructural changes in the lungs of cats Felis catus (Linnaeus, 1758) experimentally infected with D. immitis (Leidy, 1856)
Authors: Maia, Frederico C. L.
McCall, John W.
Silva, Valdemiro A.
Peixoto, Cristina A.
Supakorndej, Prasit
Supakorndej, Nonglak
Alves, Leucio C.
Affilliation: Departamento de Medicina Veterinária. Recife, PE, Brasil.
University of Georgia. College of Veterinary Medicine. Athens, GA, USA.
Departamento de Medicina Veterinária. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhaes. Recife, PE, Brasil.
TRS Labs Inc. Athens, GA, USA.
TRS Labs Inc. Athens, GA, USA.
Departamento de Medicina Veterinária. Recife, PE, Brasil.
Abstract: Clinical signs are seldom observed in feline heartworm disease, and the pathophysiological changes in the lungs of infected animals remain undefined. The goal of this study was to evaluate the structural and ultrastructural changes in the lungs of cats experimentally infected with Dirofilaria immitis. Six healthy cats were each infected with two adult heartworms by intravenous transplantation (Receptor Group, RG). The control group consisted of two uninfected animals kept under the same conditions as the RG. At 42 days after transplantation, all cats were euthanized and necropsied for worm recovery and collection of lung samples for examination by light microscopy (LM) and transmission electron microscopy. By LM, lung sections from the six infected cats exhibited bronchial and bronchiolar lesions. Alterations in all tissues of the pulmonary arteries were observed in the infected animals. In conclusion, cats infected experimentally with D. immitis developed lesions in their lungs as a consequence of arterial disease and intense interstitial pneumonia.
Keywords: Feline heartworm
Light microscopy
Transmission electron microscopy
DeCS: Animais
Doenças do Gato / parasitologia
Doenças do gato / patologia
Dirofilaria immitis / pathogenicity
Dirofilariose / parasitologia
Dirofilariose / patologia
Pulmão / parasitologia
Pulmão / patologia
Pulmão / ultraestrutura
Microscopia Eletrônica de Transmissão / veterinária
Artéria Pulmonar / parasitologia
Artéria Pulmonar / patologia
Artéria Pulmonar / ultraestrutura
Issue Date: 2011
Citation: MAIA, Frederico C. L. et al. Structural and Ultrastructural Changes in the Lungs of Cats Felis Catus (Linnaeus, 1758) Experimentally Infected with D. Immitis (Leidy, 1856). Veterinary Parasitology, v. 176, n. 4, p. 304–312, 22 mar. 2011.
DOI: 10.1016/j.vetpar.2011.01.014
ISSN: 1873-2550
Copyright: restricted access
Appears in Collections:PE - IAM - Artigos de Periódicos

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